# GeDiPNet Cluster 238 -- Enriched Pathways -- generated 2026-10-07 05:39:32
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Regulation of Complement cascade	Reactome	12	CFHR1, CFI, C2, C3, C9, CFB, CFH, CFHR4, CFHR5, CD46, SERPING1, CFHR3	47	209	14.67	1.722e-11	2.925e-9
Complement and coagulation cascades	KEGG	12	CFHR1, CFI, C2, C3, C9, CFB, CFH, CFHR4, CFHR5, CD46, SERPING1, CFHR3	88	209	7.84	3.620e-8	2.687e-6
Collagen chain trimerization	Reactome	8	COL4A3, COL8A1, COL10A1, COL22A1, COL2A1, COL9A3, COL4A2, COL4A4	44	209	10.45	7.612e-7	3.846e-5
Fluid shear stress and atherosclerosis	KEGG	13	MMP9, GSTM1, GSTP1, GSTT1, KDR, NOS3, VEGFA, MMP2, NFE2L2, NQO1, PDGFB, SQSTM1	141	209	5.30	1.032e-6	5.018e-5
Collagen biosynthesis and modifying enzymes	Reactome	9	COL4A3, COL8A1, COL10A1, COL22A1, COL2A1, COL9A3, CRTAP, COL4A2, COL4A4	67	209	7.72	2.199e-6	9.538e-5
Assembly of collagen fibrils and other multimeric structures	Reactome	8	COL4A3, COL8A1, MMP9, COL10A1, COL2A1, COL9A3, COL4A2, COL4A4	51	209	9.01	2.464e-6	1.055e-4
Non-integrin membrane-ECM interactions	Reactome	6	COL4A3, COL10A1, PDGFB, COL2A1, COL4A2, COL4A4	24	209	14.37	2.678e-6	1.132e-4
Collagen degradation	Reactome	8	COL4A3, COL8A1, MMP9, COL10A1, MMP2, COL2A1, COL4A2, COL4A4	52	209	8.84	2.868e-6	1.198e-4
Protein digestion and absorption	KEGG	10	COL4A3, COL8A1, CTRB2, ELN, COL10A1, COL22A1, COL2A1, COL9A3, COL4A2, COL4A4	103	209	5.58	1.185e-5	3.860e-4
The canonical retinoid cycle in rods (twilight vision)	Reactome	5	ABCA4, RDH5, RLBP1, RHO, RPE65	20	209	14.37	1.906e-5	5.766e-4
Signaling by PDGF	Reactome	6	COL4A3, PDGFB, COL2A1, COL9A3, COL4A2, COL4A4	33	209	10.45	1.934e-5	5.828e-4
ECM-receptor interaction	KEGG	9	COL4A3, COL2A1, COL9A3, FRAS1, LAMA2, COL4A2, COL4A4, TNR, TNXB	89	209	5.81	2.349e-5	6.810e-4
NCAM1 interactions	Reactome	5	COL4A3, COL2A1, COL9A3, COL4A2, COL4A4	21	209	13.68	2.467e-5	7.091e-4
Focal adhesion	KEGG	13	COL4A3, FLT1, KDR, VEGFA, PDGFB, COL2A1, COL9A3, LAMA2, COL4A2, COL4A4, SRC, TNR	203	209	3.68	5.472e-5	1.376e-3
Relaxin signaling pathway	KEGG	10	COL4A3, MMP9, TGFBR1, NOS3, VEGFA, MMP2, COL4A2, COL4A4, RXFP2, SRC	130	209	4.42	8.905e-5	2.042e-3