# GeDiPNet Cluster 235 -- Enriched Pathways -- generated 2026-10-09 05:04:54
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Antifolate resistance	KEGG	11	ABCC2, ABCG2, DHFR, MTHFR, SHMT1, SLC19A1, TNF, TYMS, ABCC1, ALOX12, IL6	30	303	14.53	7.844e-11	1.088e-8
Folate transport and metabolism	KEGG	8	ABCC2, ABCG2, DHFR, MTHFR, SHMT1, SLC19A1, TYMS, ABCC1	31	303	10.23	7.122e-7	3.473e-5
Lipid and atherosclerosis	KEGG	17	CASP3, CASP9, CYP2C8, CYP2C9, FOS, NFATC2, TNF, TP53, ABCA1, ICAM1, IL6, JUN	216	303	3.12	3.350e-5	8.948e-4
Caspase activation via Dependence Receptors in the absence of ligand	Reactome	3	CASP3, CASP9, DCC	4	303	29.73	6.242e-5	1.483e-3
Platinum drug resistance	KEGG	9	MGST1, ABCC2, CASP3, CASP9, TP53, CDKN2A, ERCC1, GSTP1, GSTT1	75	303	4.76	1.071e-4	2.311e-3
Viral protein interaction with cytokine and cytokine receptor	KEGG	10	XCL2, TNF, IL6, TNFRSF10A, CCL17, CX3CL1, CXCL12, IL2RA, IL37, IL6R	100	303	3.96	2.097e-4	3.941e-3
Pathways in cancer	KEGG	27	MGST1, RARB, SLC2A1, CASP3, CASP9, FOS, HES5, NOTCH1, PTGS2, TP53, CDKN2A, DAPK1	533	303	2.01	4.493e-4	7.253e-3
Pathways of neurodegeneration - multiple diseases	KEGG	25	DNAH8, BDNF, CASP3, CASP9, NOS1, PTGS2, SLC6A3, SOD1, TNF, CACNA1B, IL6, ND1	480	303	2.06	4.879e-4	7.730e-3
IL-17 signaling pathway	KEGG	9	CASP3, CSF3, FOS, PTGS2, TNF, IL6, JUN, MMP3, CCL17	94	303	3.80	5.975e-4	9.042e-3
Apoptosis	KEGG	11	CASP3, CASP9, FOS, NGF, TNF, TP53, JUN, TNFRSF10A, AIFM1, LMNA, SPTAN1	137	303	3.18	6.931e-4	1.015e-2
Metabolism of folate and pterines	Reactome	4	DHFR, MTHFR, SHMT1, SLC19A1	17	303	9.33	7.289e-4	1.055e-2
TNF signaling pathway	KEGG	10	CASP3, FOS, PTGS2, TNF, ICAM1, IL6, JUN, MMP3, CX3CL1, MAP2K6	119	303	3.33	8.469e-4	1.174e-2
ABC transporters	KEGG	6	ABCB1, ABCC2, ABCG2, ABCA1, ABCC1, ABCA4	45	303	5.28	8.729e-4	1.203e-2
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Reactome	3	NFATC2, CTLA4, IL2RA	10	303	11.89	1.673e-3	1.997e-2
Chemical carcinogenesis - DNA adducts	KEGG	7	MGST1, CYP2C8, CYP2C9, PTGS2, GSTP1, GSTT1, NAT2	70	303	3.96	1.868e-3	2.175e-2