# GeDiPNet Cluster 23 -- Enriched Pathways -- generated 2026-10-07 04:51:00
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Fluid shear stress and atherosclerosis	KEGG	14	GSTM1, MMP9, NOS3, GSTT1, MMP2, PLAT, TRPV4, PIK3CA, ACTB, ACVR1, MAPK14, TNF	141	189	6.31	4.448e-8	3.215e-6
Estrogen signaling pathway	KEGG	13	MMP9, NOS3, MMP2, ESR2, PIK3CA, SP1, ATF4, GNAS, POMC, OPRM1, TGFA, HSPA1B	139	189	5.94	2.769e-7	1.594e-5
Lipid and atherosclerosis	KEGG	15	MMP9, NOS3, CYP1A1, PIK3CA, APOA1, ATF4, SOD2, ABCG1, PPARG, MAPK14, NLRP3, TNF	216	189	4.41	1.573e-6	7.195e-5
Opioid Signalling	Reactome	3	PDYN, POMC, OPRM1	3	189	63.54	3.837e-6	1.532e-4
Hormone signaling	KEGG	14	ESR2, PIK3CA, GNAS, NOS1, NPPA, PDYN, POMC, OPRM1, ACVR1, ADIPOQ, GHRH, ADRA2A	219	189	4.06	9.244e-6	3.142e-4
Pathways in cancer	KEGG	23	GSTM1, HGF, MMP9, F2, GSTT1, IL23R, MMP2, AR, ESR2, HHIP, PIK3CA, SP1	533	189	2.74	1.065e-5	3.535e-4
Prostate cancer	KEGG	9	MMP9, PLAT, AR, PIK3CA, SRD5A2, ATF4, TGFA, GSTP1, TCF7L2	98	189	5.84	2.306e-5	6.711e-4
Interleukin-4 and Interleukin-13 signaling	Reactome	9	HGF, MMP9, IL23R, MMP2, POMC, OPRM1, IL17A, TNF, FN1	108	189	5.30	5.008e-5	1.280e-3
Hepatocellular carcinoma	KEGG	11	GSTM1, HGF, GSTT1, PIK3CA, WNT11, WNT8A, ACTB, TXNRD2, TGFA, GSTP1, TCF7L2	170	189	4.11	7.700e-5	1.813e-3
Platelet activation	KEGG	9	NOS3, F2, PIK3CA, ACTB, GNAS, MAPK14, GUCY1A1, PLCB3, PRKG2	126	189	4.54	1.654e-4	3.365e-3
AGE-RAGE signaling pathway in diabetic complications	KEGG	8	NOS3, MMP2, PIK3CA, EGR1, MAPK14, TNF, FN1, PLCB3	101	189	5.03	1.881e-4	3.732e-3
Relaxin signaling pathway	KEGG	9	MMP9, NOS3, MMP2, PIK3CA, ATF4, GNAS, NOS1, MAPK14, PLCB3	130	189	4.40	2.096e-4	4.049e-3
Extra-nuclear estrogen signaling	Reactome	6	MMP9, NOS3, MMP2, ESR2, PIK3CA, TGFA	58	189	6.57	2.878e-4	5.191e-3
One carbon pool by folate	KEGG	5	MTHFR, AHCY, ALDH1L1, SARDH, ATIC	38	189	8.36	3.014e-4	5.383e-3
HDL remodeling	Reactome	3	APOE, APOA1, ABCG1	10	189	19.06	4.243e-4	7.011e-3