# GeDiPNet Cluster 224 -- Enriched Pathways -- generated 2026-10-07 03:16:36
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Ovarian steroidogenesis	KEGG	2	INS, CYP17A1	52	9	51.32	6.492e-4	9.774e-3
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)	Reactome	1	CYP17A1	1	9	1334.44	7.494e-4	1.092e-2
Prolactin signaling pathway	KEGG	2	INS, CYP17A1	71	9	37.59	1.208e-3	1.562e-2
Signaling by Insulin receptor	Reactome	1	INS	2	9	667.22	1.498e-3	1.846e-2
Insulin secretion	KEGG	2	INS, CHRM3	86	9	31.03	1.766e-3	2.084e-2
Muscarinic acetylcholine receptors	Reactome	1	CHRM3	5	9	266.89	3.742e-3	3.593e-2
IRS activation	Reactome	1	INS	5	9	266.89	3.742e-3	3.593e-2
Insulin receptor signalling cascade	Reactome	1	INS	6	9	222.41	4.489e-3	4.079e-2
Glucocorticoid biosynthesis	Reactome	1	CYP17A1	10	9	133.44	7.471e-3	5.688e-2
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Reactome	1	INS	10	9	133.44	7.471e-3	5.688e-2
Signal attenuation	Reactome	1	INS	10	9	133.44	7.471e-3	5.688e-2
Androgen biosynthesis	Reactome	1	CYP17A1	11	9	121.31	8.216e-3	6.072e-2
Insulin processing	Reactome	1	INS	14	9	95.32	1.045e-2	7.047e-2
Hormone signaling	KEGG	2	INS, VIP	219	9	12.19	1.095e-2	7.246e-2
Extracellular matrix organization	Reactome	1	COL4A5	15	9	88.96	1.119e-2	7.338e-2