# GeDiPNet Cluster 220 -- Enriched Pathways -- generated 2026-10-08 00:00:37
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
AGE-RAGE signaling pathway in diabetic complications	KEGG	44	AGT, CXCL8, EGR1, ICAM1, IL6, MAPK13, MAPK14, RELA, SERPINE1, TNF, VCAM1, COL1A1	101	692	7.56	3.060e-28	7.223e-25
Lipid and atherosclerosis	KEGG	58	CXCL2, CXCL8, CYP2B6, ICAM1, IL6, LY96, MAPK13, MAPK14, NFE2L2, RELA, TLR2, TNF	216	692	4.66	5.926e-24	8.323e-21
Interleukin-4 and Interleukin-13 signaling	Reactome	41	CXCL8, ICAM1, IL6, NOS2, POMC, TNF, VCAM1, FOS, IL1B, MMP2, MMP9, TGFB1	108	692	6.59	1.360e-23	1.734e-20
Chagas disease	KEGG	39	CXCL8, IL6, MAPK13, MAPK14, NOS2, RELA, SERPINE1, TLR2, TNF, FOS, IL1B, JUN	103	692	6.57	1.890e-22	2.097e-19
Leishmaniasis	KEGG	34	MAPK13, MAPK14, NOS2, RELA, TLR2, TNF, FOS, IL1B, JUN, MAP3K7, MAPK1, MAPK3	78	692	7.57	4.284e-22	4.485e-19
Toxoplasmosis	KEGG	40	LY96, MAPK13, MAPK14, NOS2, RELA, TLR2, TNF, MAP3K7, MAPK1, MAPK3, MAPK8, MAPK9	112	692	6.20	6.889e-22	6.705e-19
Interleukin-10 signaling	Reactome	27	CXCL2, CXCL8, ICAM1, IL6, TNF, IL1B, TIMP1, CCL2, CCL5, IL10, PTGS2, TNFRSF1B	47	692	9.97	6.864e-22	6.705e-19
Alcoholic liver disease	KEGG	44	ALDH1B1, CXCL2, CXCL8, IL6, LY96, MAPK13, MAPK14, PRKAG2, RELA, TNF, IL1B, MAP3K7	144	692	5.30	7.469e-21	5.676e-18
Pathways in cancer	KEGG	88	ADCY9, AGT, CXCL8, F2RL3, IGF1, IL6, NFE2L2, NOS2, NQO1, RELA, FOS, JUN	533	692	2.87	6.784e-20	4.585e-17
Fluid shear stress and atherosclerosis	KEGG	41	ICAM1, MAPK13, MAPK14, NFE2L2, NQO1, RELA, TNF, VCAM1, FOS, IL1B, JUN, KEAP1	141	692	5.05	1.249e-18	7.073e-16
Toll-like receptor signaling pathway	KEGG	36	CXCL8, IL6, LY96, MAPK13, MAPK14, RELA, TLR2, TNF, FOS, IL1B, JUN, MAP3K7	109	692	5.73	1.586e-18	8.890e-16
Th17 cell differentiation	KEGG	34	IL6, MAPK13, MAPK14, RELA, FOS, IL1B, JUN, MAPK1, MAPK3, MAPK8, MAPK9, TGFB1	109	692	5.41	1.066e-16	4.379e-14
Relaxin signaling pathway	KEGG	37	ADCY9, MAPK13, MAPK14, NOS2, RELA, ACTA2, COL1A1, COL3A1, FOS, JUN, MAPK1, MAPK3	130	692	4.94	1.359e-16	5.425e-14
Influenza A	KEGG	42	CXCL8, ICAM1, IL6, RELA, TNF, IL1B, MAPK1, MAPK3, MYD88, TLR4, HLA-DPB1, HLA-DQB1	173	692	4.21	6.370e-16	2.325e-13
Inflammatory bowel disease	KEGG	26	IL6, RELA, TLR2, TNF, IL1B, JUN, TGFB1, TLR4, MAF, HLA-DPB1, HLA-DQB1, HLA-DPA1	66	692	6.84	6.967e-16	2.510e-13