# GeDiPNet Cluster 22 -- Pairs Within Cluster -- generated 2026-10-08 08:16:51
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected across all tested pairs. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:00:12.
Disease A	Disease B	Similarity Score	Shared Genes	P-value	FDR Q-value
Leber hereditary optic neuropathy	Melas syndrome	0.46875	15	6.188e-41	2.658e-39
Cleft palate and bilateral cleft lip	Postaxial polydactyly	0.50000	12	7.235e-35	2.605e-33
Cleft palate and bilateral cleft lip	Neuropathy, ataxia, and retinitis pigmentosa	0.64706	11	9.855e-35	3.530e-33
Neuropathy, ataxia, and retinitis pigmentosa	Postaxial polydactyly	0.45833	11	9.541e-32	3.080e-30
Leber hereditary optic neuropathy	Neuropathy, ataxia, and retinitis pigmentosa	0.35484	11	5.804e-30	1.778e-28
Cleft palate and bilateral cleft lip	Leber hereditary optic neuropathy	0.34375	11	2.706e-29	8.063e-28
Leber hereditary optic neuropathy	Rod-cone dystrophy	0.26531	13	4.822e-29	1.429e-27
Neuropathy, ataxia, and retinitis pigmentosa	Rod-cone dystrophy	0.30556	11	5.228e-29	1.547e-27
Melas syndrome	Neuropathy, ataxia, and retinitis pigmentosa	0.45455	10	6.070e-29	1.791e-27
Cleft palate and bilateral cleft lip	Melas syndrome	0.43478	10	2.124e-28	6.144e-27
Cleft palate and bilateral cleft lip	Rod-cone dystrophy	0.29730	11	2.436e-28	7.030e-27
Postaxial polydactyly	Rod-cone dystrophy	0.27907	12	2.792e-28	8.034e-27
Leber hereditary optic neuropathy	Postaxial polydactyly	0.28205	11	2.603e-26	6.799e-25
Melas syndrome	Postaxial polydactyly	0.33333	10	7.458e-26	1.898e-24
Melas syndrome	Rod-cone dystrophy	0.23810	10	1.946e-23	4.377e-22
Mitochondrial myopathy	Progressive external ophthalmoplegia	0.20833	5	5.338e-13	6.639e-12
Melas syndrome	Progressive external ophthalmoplegia	0.18519	5	1.521e-12	1.821e-11
Neuropathy, ataxia, and retinitis pigmentosa	Optic neuropathy	0.21053	4	3.839e-11	3.985e-10
Cleft palate and bilateral cleft lip	Optic neuropathy	0.20000	4	5.373e-11	5.531e-10
Melas syndrome	Optic neuropathy	0.16667	4	1.641e-10	1.608e-9
Optic neuropathy	Postaxial polydactyly	0.14815	4	3.207e-10	3.066e-9
Developmental delay	Melas syndrome	0.09615	5	5.829e-10	5.414e-9
Melas syndrome	Myoclonic epilepsy with ragged red fibers	0.15789	3	1.341e-9	1.206e-8
Developmental delay	Leber hereditary optic neuropathy	0.08065	5	6.567e-9	5.511e-8
Developmental delay	Neuropathy, ataxia, and retinitis pigmentosa	0.08333	4	2.219e-8	1.732e-7
Cleft palate and bilateral cleft lip	Developmental delay	0.08163	4	3.100e-8	2.352e-7
Developmental delay	Postaxial polydactyly	0.07143	4	1.831e-7	1.224e-6
Melas syndrome	Mitochondrial myopathy	0.09677	3	6.050e-7	3.703e-6
Congenital cardiomyopathy	Neuropathy, ataxia, and retinitis pigmentosa	0.14286	2	6.580e-7	4.002e-6
Cleft palate and bilateral cleft lip	Congenital cardiomyopathy	0.13333	2	7.677e-7	4.587e-6
Congenital cardiomyopathy	Melas syndrome	0.10526	2	1.291e-6	7.448e-6
Congenital cardiomyopathy	Postaxial polydactyly	0.09091	2	1.772e-6	9.988e-6
Myoclonic epilepsy with ragged red fibers	Progressive external ophthalmoplegia	0.13333	2	1.973e-6	1.099e-5
Mitochondrial myopathy	Myoclonic epilepsy with ragged red fibers	0.11765	2	2.656e-6	1.449e-5
Optic neuropathy	Stomatitis	0.10526	2	1.666e-5	8.006e-5
Developmental delay	Mitochondrial encephalopathy	0.05000	2	1.776e-5	8.505e-5
Congenital cardiomyopathy	Myoclonic epilepsy with ragged red fibers	0.20000	1	3.896e-4	8.637e-4
Optic neuropathy	Periodic paralysis with later-onset distal motor neuropathy	0.10000	1	5.845e-4	1.154e-3
nijmegen breakage syndrome	Stomatitis	0.08333	1	7.144e-4	1.333e-3
Neuropathy, ataxia, and retinitis pigmentosa	Periodic paralysis with later-onset distal motor neuropathy	0.07143	1	8.443e-4	1.497e-3
Cleft palate and bilateral cleft lip	Periodic paralysis with later-onset distal motor neuropathy	0.06667	1	9.092e-4	1.575e-3
Melas syndrome	Periodic paralysis with later-onset distal motor neuropathy	0.05263	1	1.169e-3	1.894e-3
Developmental delay	Intellectual developmental disorder seizures language	0.02564	1	2.468e-3	3.370e-3
Developmental delay	Developmental delay with variable neurological abnormalities	0.02564	1	2.468e-3	3.370e-3
Developmental delay	Developmental delay with hypotonia and impaired language	0.02564	1	2.468e-3	3.370e-3
Mitochondrial encephalopathy	Neuropathy, ataxia, and retinitis pigmentosa	0.06250	1	2.531e-3	3.446e-3
Cleft palate and bilateral cleft lip	Mitochondrial encephalopathy	0.05882	1	2.725e-3	3.664e-3