# GeDiPNet Cluster 219 -- Enriched GO Terms (Biological Process) -- generated 2026-10-08 09:03:22
# GO term enrichment: Biological Process terms (gene2go, human/tax_id=9606 only), upper-tail hypergeometric test, fold enrichment = (overlap / cluster gene count) / (term gene count / universe size), Benjamini-Hochberg FDR-corrected. Top 15 terms per cluster by q-value. See scripts/build_cluster_go_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:23:04.
GO Term	GO ID	Overlap Genes	Overlap Gene Names	Term Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
response to gamma radiation	GO:0010332	9	BAK1, BCL2, GATA3, POLB, TP53, BRCA2, LIG4, PARP1, SOD2	27	337	18.48	6.387e-10	1.456e-7
release of cytochrome c from mitochondria	GO:0001836	8	BAK1, BCL2, SMAD3, PMAIP1, TP53, BCL2L1, MCL1, SOD2	23	337	19.29	3.988e-9	7.446e-7
apoptotic process	GO:0006915	38	APP, BAK1, BCL2, BCL2L11, BMF, BUB1B, CASP10, CASP8, CFLAR, CLPTM1L, CSRNP1, FAS	747	337	2.82	8.733e-9	1.484e-6
positive regulation of transcription by RNA polymerase II	GO:0045944	49	APP, ASCL2, CSRNP1, DRD2, EOMES, ETS1, FLI1, IRF4, IRF8, LEF1, NCK1, PRKD2	1208	337	2.25	8.040e-8	1.014e-5
positive regulation of apoptotic process	GO:0043065	22	APP, BAK1, BCL2, BCL2L11, BMF, CASP8, FAS, IRF8, SPDEF, EPHA7, LPAR1, ATM	326	337	3.74	1.279e-7	1.506e-5
intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9	BAK1, BCL2, BCL2L11, ATM, POLB, BCL2L1, BRCA2, MCL1, SOD2	54	337	9.24	4.722e-7	4.505e-5
regulation of T-helper cell differentiation	GO:0045622	4	HLA-DRB1, IRF4, GATA3, HLA-DRA	5	337	44.36	5.122e-7	4.835e-5
positive regulation of DNA-templated transcription	GO:0045893	35	CXXC1, EOMES, ETS1, FLI1, HLA-DRB1, IRF4, IRF8, LEF1, MAP2K2, RFX7, RREB1, SMAD3	778	337	2.49	6.692e-7	6.018e-5
reactive oxygen species metabolic process	GO:0072593	8	BCL2, IL19, P2RX7, PMAIP1, TP53, BNIP3, PDGFB, PREX1	45	337	9.86	1.241e-6	9.970e-5
positive regulation of T cell activation	GO:0050870	8	HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRB1, CORO1A, HLA-DRA, TNFSF11, CCL2	45	337	9.86	1.241e-6	9.970e-5
regulation of mitochondrial membrane permeability	GO:0046902	5	BAK1, BCL2, PMAIP1, BCL2L1, BNIP3	12	337	23.10	1.322e-6	1.049e-4
positive regulation of neuron apoptotic process	GO:0043525	9	APP, BCL2L11, CASP10, CASP8, CFLAR, EPHA7, ATM, TP53, MCL1	65	337	7.68	2.385e-6	1.690e-4
positive regulation of ERK1 and ERK2 cascade	GO:0070374	15	ACTA2, APP, CFLAR, DRD2, HLA-DRB1, OPRM1, PRKD2, MAPK3, PDGFD, PTPN22, SERPINF2, TNFRSF11A	201	337	4.14	3.904e-6	2.511e-4
regulation of apoptotic process	GO:0042981	17	BAK1, BCL2, BCL2L11, CASP10, CASP8, CFLAR, ETS1, FAS, PHLPP1, ZBTB7A, LRP5, ATM	254	337	3.71	3.924e-6	2.519e-4
positive regulation of release of cytochrome c from mitochondria	GO:0090200	6	BAK1, BCL2L11, BMF, PMAIP1, TP53, BNIP3	25	337	13.31	4.362e-6	2.745e-4