# GeDiPNet Cluster 219 -- Enriched Pathways -- generated 2026-10-07 03:14:07
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Alcoholic liver disease	KEGG	4	LPIN2, C1QA, LBP, NFKBIA	144	10	33.36	3.936e-6	1.560e-4
Interleukin-1 signaling	Reactome	3	IL1R1, IL1RN, NFKBIA	88	10	40.94	4.395e-5	1.150e-3
NF-kappa B signaling pathway	KEGG	3	IL1R1, LBP, NFKBIA	105	10	34.31	7.453e-5	1.761e-3
Interleukin-10 signaling	Reactome	2	IL1R1, IL1RN	47	10	51.11	6.612e-4	9.913e-3
Human T-cell leukemia virus 1 infection	KEGG	3	IL1R1, HLA-B, NFKBIA	224	10	16.08	6.973e-4	1.034e-2
Human cytomegalovirus infection	KEGG	3	IL1R1, HLA-B, NFKBIA	226	10	15.94	7.156e-4	1.054e-2
Coronavirus disease - COVID-19	KEGG	3	C1QA, VWF, NFKBIA	238	10	15.14	8.319e-4	1.182e-2
Transfer of LPS from LBP carrier to CD14	Reactome	1	LBP	2	10	600.50	1.665e-3	1.998e-2
Cytosolic DNA-sensing pathway	KEGG	2	MLKL, NFKBIA	83	10	28.94	2.048e-3	2.323e-2
Complement and coagulation cascades	KEGG	2	C1QA, VWF	88	10	27.30	2.299e-3	2.529e-2
Chagas disease	KEGG	2	C1QA, NFKBIA	103	10	23.32	3.134e-3	3.176e-2
Toll-like receptor signaling pathway	KEGG	2	LBP, NFKBIA	109	10	22.04	3.502e-3	3.427e-2
Th17 cell differentiation	KEGG	2	IL1R1, NFKBIA	109	10	22.04	3.502e-3	3.427e-2
TNF signaling pathway	KEGG	2	MLKL, NFKBIA	119	10	20.18	4.159e-3	3.874e-2
Classical antibody-mediated complement activation	Reactome	1	C1QA	6	10	200.17	4.986e-3	4.365e-2