# GeDiPNet Cluster 216 -- Enriched Pathways -- generated 2026-10-08 05:02:18
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
MET activates PTK2 signaling	Reactome	3	LAMB1, COL24A1, COL5A1	30	34	35.32	7.988e-5	1.886e-3
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	Reactome	2	RXRA, AKR1C4	15	34	47.10	7.982e-4	1.172e-2
IL-6-type cytokine receptor ligand interactions	Reactome	2	TYK2, LIFR	17	34	41.56	1.030e-3	1.420e-2
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Reactome	2	RXRA, AKR1C4	24	34	29.44	2.065e-3	2.384e-2
Dopamine clearance from the synaptic cleft	Reactome	1	SLC6A3	1	34	353.24	2.831e-3	3.003e-2
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	Reactome	1	SLC6A3	1	34	353.24	2.831e-3	3.003e-2
Th17 cell differentiation	KEGG	3	RXRA, HLA-DRB4, TYK2	109	34	9.72	3.546e-3	3.514e-2
Toxoplasmosis	KEGG	3	LAMB1, HLA-DRB4, TYK2	112	34	9.46	3.828e-3	3.711e-2
Allograft rejection	KEGG	2	HLA-A, HLA-DRB4	39	34	18.11	5.398e-3	4.702e-2
N-glycan trimming and elongation in the cis-Golgi	Reactome	1	MANEA	2	34	176.62	5.654e-3	4.850e-2
Formation of the cornified envelope	Reactome	3	KRT3, KRT4, KRT13	130	34	8.15	5.804e-3	4.943e-2
Type I diabetes mellitus	KEGG	2	HLA-A, HLA-DRB4	44	34	16.06	6.831e-3	5.492e-2
Collagen chain trimerization	Reactome	2	COL24A1, COL5A1	44	34	16.06	6.831e-3	5.492e-2
Graft-versus-host disease	KEGG	2	HLA-A, HLA-DRB4	45	34	15.70	7.136e-3	5.653e-2
Keratinization	Reactome	3	KRT3, KRT4, KRT13	152	34	6.97	8.924e-3	6.534e-2