# GeDiPNet Cluster 214 -- Enriched Pathways -- generated 2026-10-07 03:16:19
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Prostate cancer	KEGG	14	BRAF, CCND1, CDKN1B, MAPK1, MAPK3, RAF1, CREBBP, PTEN, RB1, TP53, ZEB1, EGFR	98	148	11.59	1.345e-11	2.336e-9
Melanoma	KEGG	11	BRAF, CCND1, MAPK1, MAPK3, RAF1, CDKN2A, PTEN, RB1, TP53, EGFR, FGFR1	73	148	12.23	1.266e-9	1.370e-7
Non-small cell lung cancer	KEGG	11	BRAF, CCND1, MAPK1, MAPK3, RAF1, RASSF5, CDKN2A, PLCG1, RB1, TP53, EGFR	73	148	12.23	1.266e-9	1.370e-7
Bladder cancer	KEGG	9	BRAF, CCND1, MAPK1, MAPK3, RAF1, CDKN2A, RB1, TP53, EGFR	41	148	17.81	1.285e-9	1.389e-7
Pathways in cancer	KEGG	26	BRAF, CCND1, CDKN1B, GSTT1, IL2, MAPK1, MAPK3, PTGS2, RAF1, RASSF5, VHL, CDKN2A	533	148	3.96	1.483e-9	1.577e-7
Glioma	KEGG	11	BRAF, CCND1, MAPK1, MAPK3, RAF1, CDKN2A, PLCG1, PTEN, RB1, TP53, EGFR	76	148	11.75	1.975e-9	2.034e-7
Human T-cell leukemia virus 1 infection	KEGG	17	CCND1, IL2, MAPK1, MAPK3, RANBP1, CDKN2A, CREBBP, IL2RG, PTEN, RB1, TP53, ADCY1	224	148	6.16	2.131e-9	2.173e-7
Hepatocellular carcinoma	KEGG	14	BRAF, CCND1, GSTT1, MAPK1, MAPK3, RAF1, ARID1A, CDKN2A, PLCG1, PTEN, RB1, SMARCA4	170	148	6.68	2.154e-8	1.714e-6
Pancreatic cancer	KEGG	10	BRAF, CCND1, MAPK1, MAPK3, RAF1, CDKN2A, RB1, TP53, BRCA2, EGFR	77	148	10.54	3.224e-8	2.441e-6
Endocrine resistance	KEGG	11	BRAF, CCND1, CDKN1B, MAPK1, MAPK3, RAF1, CDKN2A, RB1, TP53, ADCY1, EGFR	99	148	9.02	3.412e-8	2.553e-6
FoxO signaling pathway	KEGG	12	BRAF, CCND1, CDKN1B, MAPK1, MAPK3, RAF1, SOD2, TNFSF10, CREBBP, PTEN, EGFR, EP300	133	148	7.32	8.374e-8	5.608e-6
Breast cancer	KEGG	12	BRAF, CCND1, MAPK1, MAPK3, RAF1, PTEN, RB1, TP53, BRCA2, EGFR, FGFR1, KIT	148	148	6.58	2.719e-7	1.566e-5
Negative feedback regulation of MAPK pathway	Reactome	4	BRAF, MAPK1, MAPK3, RAF1	6	148	54.10	3.259e-7	1.844e-5
Chronic myeloid leukemia	KEGG	9	BRAF, CCND1, CDKN1B, MAPK1, MAPK3, RAF1, CDKN2A, RB1, TP53	77	148	9.48	4.061e-7	2.234e-5
Cellular senescence	KEGG	12	CCND1, EIF4EBP1, MAPK1, MAPK3, RAF1, RASSF5, TSC2, CDKN2A, PTEN, RB1, TP53, HLA-B	157	148	6.20	5.159e-7	2.750e-5