# GeDiPNet Cluster 202 -- Enriched Pathways -- generated 2026-10-07 07:49:47
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Urea cycle	Reactome	7	ASL, CPS1, ARG1, ASS1, NAGS, OTC, SLC25A15	10	13	646.69	2.881e-20	2.306e-17
Arginine biosynthesis	KEGG	7	ASL, CPS1, ARG1, ASS1, NAGS, OTC, GLUD1	23	13	281.17	5.852e-17	2.773e-14
Biosynthesis of amino acids	KEGG	6	ASL, CPS1, ARG1, ASS1, NAGS, OTC	75	13	73.91	8.018e-11	1.181e-8
Alanine, aspartate and glutamate metabolism	KEGG	4	ASL, CPS1, ASS1, GLUD1	37	13	99.88	5.343e-8	3.783e-6
Metabolic pathways	KEGG	8	ASL, CPS1, ARG1, ASS1, NAGS, OTC, GLUD1, TYMS	1563	13	4.73	5.667e-5	1.417e-3
Nitrogen metabolism	KEGG	2	CPS1, GLUD1	17	13	108.69	1.458e-4	3.045e-3
Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3)	Reactome	1	ABCA3	1	13	923.85	1.082e-3	1.440e-2
Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3)	Reactome	1	ABCA3	1	13	923.85	1.082e-3	1.440e-2
Toll Like Receptor 5 (TLR5) Cascade	Reactome	1	TLR5	1	13	923.85	1.082e-3	1.440e-2
MyD88 deficiency (TLR5)	Reactome	1	TLR5	2	13	461.92	2.164e-3	2.417e-2
IRAK4 deficiency (TLR5)	Reactome	1	TLR5	4	13	230.96	4.323e-3	3.983e-2
Carbon metabolism	KEGG	2	CPS1, GLUD1	115	13	16.07	6.617e-3	5.275e-2
MyD88 cascade initiated on plasma membrane	Reactome	1	TLR5	9	13	102.65	9.703e-3	6.739e-2
Aspartate and asparagine metabolism	Reactome	1	SLC25A13	12	13	76.99	1.292e-2	7.945e-2
Glutamate and glutamine metabolism	Reactome	1	GLUD1	14	13	65.99	1.506e-2	8.714e-2