# GeDiPNet Cluster 200 -- Enriched Pathways -- generated 2026-10-08 15:31:18
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Hedgehog signaling pathway	KEGG	3	PTCH2, PTCH1, SUFU	56	9	71.49	7.908e-6	2.830e-4
Basal cell carcinoma	KEGG	3	PTCH2, PTCH1, SUFU	63	9	63.54	1.130e-5	3.776e-4
Pathways in cancer	KEGG	4	MITF, PTCH2, PTCH1, SUFU	533	9	10.01	4.043e-4	6.897e-3
Hedgehog 'off' state	Reactome	2	PTCH1, SUFU	56	9	47.66	7.528e-4	1.119e-2
Hedgehog 'on' state	Reactome	2	PTCH1, SUFU	70	9	38.13	1.174e-3	1.568e-2
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	Reactome	1	PAX6	7	9	190.63	5.235e-3	4.595e-2
Ligand-receptor interactions	Reactome	1	PTCH1	7	9	190.63	5.235e-3	4.595e-2
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	Reactome	1	PAX6	14	9	95.32	1.045e-2	7.203e-2
SUMOylation of transcription factors	Reactome	1	MITF	18	9	74.14	1.341e-2	8.370e-2
Activation of SMO	Reactome	1	PTCH1	18	9	74.14	1.341e-2	8.370e-2
Maturity onset diabetes of the young	KEGG	1	PAX6	26	9	51.32	1.932e-2	1.040e-1
Adherens junctions interactions	Reactome	1	CDH11	32	9	41.70	2.373e-2	1.170e-1
Degradation of GLI1 by the proteasome	Reactome	1	SUFU	57	9	23.41	4.193e-2	1.586e-1
GLI3 is processed to GLI3R by the proteasome	Reactome	1	SUFU	60	9	22.24	4.409e-2	1.629e-1
Melanoma	KEGG	1	MITF	73	9	18.28	5.341e-2	1.807e-1