# GeDiPNet Cluster 20 -- Enriched Pathways -- generated 2026-10-09 08:07:34
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Cytoskeleton in muscle cells	KEGG	26	DIAPH3, DIAPH1, TMEM43, ACTG1, COL11A1, COL11A2, MYH14, MYH9, OBSCN, COL4A3, COL4A4, COL4A5	232	519	2.59	8.071e-6	2.712e-4
NCAM1 interactions	Reactome	7	COL2A1, COL4A3, COL4A4, COL4A5, COL9A1, COL9A3, COL9A2	21	519	7.71	1.852e-5	5.481e-4
Signaling by PDGF	Reactome	8	COL2A1, COL4A3, COL4A4, COL4A5, COL9A1, COL9A3, THBS1, COL9A2	33	519	5.61	6.143e-5	1.463e-3
Collagen chain trimerization	Reactome	9	COL11A1, COL11A2, COL2A1, COL4A3, COL4A4, COL4A5, COL9A1, COL9A3, COL9A2	44	519	4.73	8.977e-5	2.000e-3
Integrin cell surface interactions	Reactome	12	TNC, COL2A1, COL4A3, COL4A4, COL4A5, COL9A1, COL9A3, THBS1, ITGA1, ITGAM, COL9A2, ITGA2	81	519	3.43	1.736e-4	3.398e-3
Focal adhesion	KEGG	21	DIAPH1, ACTG1, TNC, HGF, MET, COL2A1, COL4A3, COL4A4, COL4A5, COL9A1, COL9A3, FLNA	203	519	2.39	1.872e-4	3.614e-3
Allograft rejection	KEGG	8	HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-B, IFNG, IL2, TNF	39	519	4.75	2.166e-4	4.039e-3
MET activates PTK2 signaling	Reactome	7	COL11A1, COL11A2, HGF, MET, COL2A1, PTK2, ITGA2	30	519	5.40	2.310e-4	4.266e-3
Assembly of collagen fibrils and other multimeric structures	Reactome	9	COL11A1, COL11A2, COL2A1, COL4A3, COL4A4, COL4A5, COL9A1, COL9A3, COL9A2	51	519	4.08	2.944e-4	5.169e-3
ECM-receptor interaction	KEGG	12	TNC, COL2A1, COL4A3, COL4A4, COL4A5, COL9A1, COL9A3, DSPP, THBS1, ITGA1, COL9A2, ITGA2	89	519	3.12	4.261e-4	6.959e-3
Non-integrin membrane-ECM interactions	Reactome	6	COL11A1, COL11A2, COL2A1, COL4A3, COL4A4, COL4A5	24	519	5.79	4.374e-4	7.101e-3
Inflammatory bowel disease	KEGG	10	GATA3, STAT1, TLR4, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IFNG, IL2, TNF	66	519	3.51	4.964e-4	7.836e-3
Type I diabetes mellitus	KEGG	8	HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-B, IFNG, IL2, TNF	44	519	4.21	5.161e-4	8.063e-3
Graft-versus-host disease	KEGG	8	HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-B, IFNG, IL2, TNF	45	519	4.11	6.043e-4	9.129e-3
MET activates PTPN11	Reactome	3	HGF, MET, GAB1	5	519	13.88	7.517e-4	1.078e-2