# GeDiPNet Cluster 2 -- Enriched Pathways -- generated 2026-10-09 19:55:21
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Unblocking of NMDA receptors, glutamate binding and activation	Reactome	22	DLG2, GRIA1, GRIN2B, GRIN2C, CALM1, ACTN2, CAMK2G, GRIA4, GRIN2A, DLG4, CAMK2A, CAMK2B	22	9673	1.24	8.519e-3	6.256e-2
Type I diabetes mellitus	KEGG	41	HLA-C, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DRB5, ICA1, PTPRN2, FAS, IL1A, IL1B, IL2, INS	44	9673	1.16	1.842e-2	1.004e-1
Uptake and function of anthrax toxins	Reactome	13	ANTXR1, MAP2K3, CALM1, FURIN, MAP2K1, ANTXR2, CALM2, MAP2K4, CALM3, MAP2K2, MAP2K7, MAP2K6	13	9673	1.24	5.992e-2	1.927e-1
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Reactome	12	CYP8B1, PTGES3, TBXAS1, AKR1C3, CBR1, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, HPGDS, PTGDS	12	9673	1.24	7.441e-2	2.159e-1
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	Reactome	12	CHRNA2, CHRNA6, CHRNA7, CHRNB2, CHRNA5, CHRNA4, CHRNA3, CHRNB3, CHRNA1, CHRFAM7A, CHRNA9, CHRNB4	12	9673	1.24	7.441e-2	2.159e-1
Activation of Ca-permeable Kainate Receptor	Reactome	12	GRIK1, GRIK2, GRIK3, CALM1, GRIK4, DLG4, CALM2, DLG3, GRIK5, CALM3, NCALD, DLG1	12	9673	1.24	7.441e-2	2.159e-1
Drug metabolism - cytochrome P450	KEGG	64	ADH5, CYP1A2, CYP2D6, GSTM3, GSTO1, GSTO2, GSTP1, GSTT1, MAOA, MAOB, UGT1A10, UGT1A8	73	9673	1.09	7.623e-2	2.191e-1
cGMP effects	Reactome	11	PDE10A, PDE1A, PDE9A, PRKG1, PDE11A, IRAG1, ITPR1, PDE5A, PDE2A, PDE1B, PRKG2	11	9673	1.24	9.241e-2	2.419e-1
Signaling by ERBB4	Reactome	11	EGFR, ERBB3, ERBB4, HBEGF, EREG, NRG3, NRG2, EGF, NRG1, BTC, NRG4	11	9673	1.24	9.241e-2	2.419e-1
Tryptophan catabolism	Reactome	11	SLC3A2, SLC7A5, TDO2, IDO2, IDO1, AADAT, KMO, HAAO, SLC36A4, KYAT1, KYNU	11	9673	1.24	9.241e-2	2.419e-1
Signaling by activated point mutants of FGFR1	Reactome	11	FGF8, FGFR1, FGF17, FGF20, FGF9, FGF2, FGF5, FGF1, FGF23, FGF6, FGF4	11	9673	1.24	9.241e-2	2.419e-1
Maturity onset diabetes of the young	KEGG	24	HNF1B, HNF4G, RFX6, INS, HNF4A, PAX4, PAX6, GCK, HNF1A, FOXA2, HHEX, IAPP	26	9673	1.15	9.430e-2	2.450e-1
Downstream signaling of activated FGFR1	Reactome	17	FGF10, FLRT2, FGF3, FGF8, FGFR1, FGF17, FGF20, FGF9, FGF2, KL, FGF5, FLRT1	18	9673	1.17	1.086e-1	2.651e-1
PI3K events in ERBB4 signaling	Reactome	10	ERBB4, HBEGF, PIK3R1, EREG, NRG3, NRG2, NRG1, BTC, NRG4, PIK3CA	10	9673	1.24	1.148e-1	2.729e-1
Cocaine addiction	KEGG	43	GRIN2B, GRIN2C, GRIN3B, GRM3, BDNF, CDK5, CDK5R1, MAOA, MAOB, DRD2, SLC6A3, CREB5	49	9673	1.09	1.339e-1	2.959e-1