# GeDiPNet Cluster 196 -- Enriched Pathways -- generated 2026-10-07 06:30:03
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
cAMP signaling pathway	KEGG	11	ATP1A2, ATP1A3, CACNA1C, CRH, CRHR1, CRHR2, DRD2, HTR1A, KCNK2, MAPK1, PDE4D	226	68	8.60	4.909e-8	3.513e-6
Hormone signaling	KEGG	9	CRH, CRHR1, CRHR2, DRD2, MC4R, OPRK1, ACVR1, INSR, STAT5A	219	68	7.26	3.665e-6	1.473e-4
Aldosterone-regulated sodium reabsorption	KEGG	4	ATP1A2, ATP1A3, MAPK1, INSR	38	68	18.59	6.001e-5	1.482e-3
Synaptic vesicle cycle	KEGG	5	SLC17A7, SLC1A3, SLC6A3, SLC6A4, ATP6V0A1	79	68	11.18	8.170e-5	1.904e-3
Class B/2 (Secretin family receptors)	Reactome	3	CRH, CRHR1, CRHR2	18	68	29.44	1.333e-4	2.828e-3
G alpha (s) signalling events	Reactome	6	CRH, CRHR1, CRHR2, MC4R, ARRB1, PDE4D	140	68	7.57	1.363e-4	2.878e-3
Adrenergic signaling in cardiomyocytes	KEGG	6	ATP1A2, ATP1A3, CACNA1C, KCNK2, MAPK1, MYH7	154	68	6.88	2.292e-4	4.356e-3
Cushing syndrome	KEGG	6	CACNA1C, CRH, CRHR1, CRHR2, KCNK2, MAPK1	155	68	6.84	2.373e-4	4.469e-3
cGMP-PKG signaling pathway	KEGG	6	ATP1A2, ATP1A3, CACNA1C, MAPK1, MYH7, INSR	166	68	6.38	3.434e-4	5.960e-3
GnRH secretion	KEGG	4	CACNA1C, MAPK1, ARRB1, KCNN3	65	68	10.87	4.908e-4	7.860e-3
Thyroid hormone signaling pathway	KEGG	5	ATP1A2, ATP1A3, MAPK1, MYH7, NOTCH1	122	68	7.24	6.230e-4	9.476e-3
Dopaminergic synapse	KEGG	5	CACNA1C, COMT, DRD2, SLC6A3, ARRB1	132	68	6.69	8.902e-4	1.243e-2
Proteoglycans in cancer	KEGG	6	ANK3, MAPK1, PTK2, PTPN11, DROSHA, ITGB1	204	68	5.19	1.018e-3	1.374e-2
Neuroactive ligand-receptor interaction	KEGG	8	CRH, CRHR1, CRHR2, DRD2, HTR1A, MC4R, OPRK1, GABRG2	370	68	3.82	1.107e-3	1.464e-2
MAPK1 (ERK2) activation	Reactome	2	MAPK1, PTPN11	9	68	39.25	1.108e-3	1.465e-2