# GeDiPNet Cluster 194 -- Enriched Pathways -- generated 2026-10-07 12:21:55
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Diabetic cardiomyopathy	KEGG	8	AGT, ATP2A2, INS, RYR2, SLC25A4, G6PD, AGER, ACE	205	34	13.78	7.797e-8	5.251e-6
Hypertrophic cardiomyopathy	KEGG	6	AGT, ATP2A2, IGF1, RYR2, TNF, ACE	99	34	21.41	3.005e-7	1.712e-5
Renin-angiotensin system	KEGG	4	AGT, AGTR2, KLK1, ACE	23	34	61.43	4.563e-7	2.471e-5
Hormone signaling	KEGG	7	AGT, AGTR2, IGF1, INS, LEPR, SLC40A1, POMC	219	34	11.29	2.156e-6	9.373e-5
Scavenging of heme from plasma	Reactome	3	APOA1, HP, ALB	13	34	81.52	5.815e-6	2.145e-4
Dilated cardiomyopathy	KEGG	5	AGT, ATP2A2, IGF1, RYR2, TNF	105	34	16.82	1.056e-5	3.508e-4
Peptide ligand-binding receptors	Reactome	5	AGT, AGTR2, POMC, BDKRB1, BDKRB2	106	34	16.66	1.106e-5	3.647e-4
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Reactome	5	APOA1, IGF1, KLK1, SPP1, ALB	125	34	14.13	2.463e-5	7.081e-4
G alpha (i) signalling events	Reactome	6	AGT, AGTR2, POMC, BDKRB1, BDKRB2, S1PR1	249	34	8.51	6.178e-5	1.515e-3
Neuroactive ligand-receptor interaction	KEGG	7	AGT, AGTR2, LEPR, POMC, BDKRB1, BDKRB2, S1PR1	370	34	6.68	6.522e-5	1.582e-3
Calcium signaling pathway	KEGG	6	ATP2A2, RYR2, SLC25A4, BDKRB1, BDKRB2, RYR1	254	34	8.34	6.899e-5	1.654e-3
Advanced glycosylation endproduct receptor signaling	Reactome	2	AGER, S100B	8	34	88.31	2.155e-4	4.145e-3
Interleukin-4 and Interleukin-13 signaling	Reactome	4	HMOX1, TNF, POMC, S1PR1	108	34	13.08	2.330e-4	4.409e-3
Pathways of neurodegeneration - multiple diseases	KEGG	7	ATP2A2, RYR2, SLC25A4, TNF, SOD1, AGER, RYR1	480	34	5.15	3.279e-4	5.753e-3
HDL remodeling	Reactome	2	APOA1, ALB	10	34	70.65	3.451e-4	5.983e-3