# GeDiPNet Cluster 189 -- Enriched Pathways -- generated 2026-10-07 19:49:34
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Breast cancer	KEGG	8	FZD4, CTNNB1, LRP5, LRP6, DLL3, JAG2, APC, FGF16	148	47	13.81	9.213e-8	6.108e-6
Gastric cancer	KEGG	7	FZD4, CTNNB1, LRP5, LRP6, APC, SHH, FGF16	150	47	11.92	1.705e-6	7.700e-5
RNF mutants show enhanced WNT signaling and proliferation	Reactome	3	FZD4, LRP5, LRP6	8	47	95.82	3.103e-6	1.279e-4
Basal cell carcinoma	KEGG	5	FZD4, CTNNB1, GLI3, APC, SHH	63	47	20.28	4.375e-6	1.701e-4
Pathways in cancer	KEGG	11	FZD4, CTNNB1, LRP5, LRP6, AGT, GLI3, DLL3, JAG2, APC, SHH, FGF16	533	47	5.27	4.823e-6	1.846e-4
Disassembly of the destruction complex and recruitment of AXIN to the membrane	Reactome	4	CTNNB1, LRP5, LRP6, APC	30	47	34.07	5.236e-6	1.970e-4
Activation of SMO	Reactome	3	IHH, IQCE, SHH	18	47	42.59	4.399e-5	1.150e-3
Wnt signaling pathway	KEGG	6	FZD4, CTNNB1, LRP5, LRP6, CSNK2B, APC	174	47	8.81	5.566e-5	1.397e-3
Hedgehog signaling pathway	KEGG	4	IHH, GLI3, IQCE, SHH	56	47	18.25	6.514e-5	1.580e-3
Regulation of FZD by ubiquitination	Reactome	3	FZD4, LRP5, LRP6	21	47	36.50	7.111e-5	1.698e-3
HHAT G278V abrogates palmitoylation of Hh-Np	Reactome	2	IHH, SHH	4	47	127.77	8.949e-5	2.051e-3
Release of Hh-Np from the secreting cell	Reactome	2	IHH, SHH	7	47	73.01	3.109e-4	5.517e-3
Ligand-receptor interactions	Reactome	2	IHH, SHH	7	47	73.01	3.109e-4	5.517e-3
Cell adhesion molecules	KEGG	5	CLDN12, CLDN14, HLA-B, HLA-DRB1, PTPRD	160	47	7.99	3.849e-4	6.518e-3
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	Reactome	2	LRP5, LRP6	8	47	63.88	4.135e-4	6.879e-3