# GeDiPNet Cluster 183 -- Enriched Pathways -- generated 2026-10-07 14:45:11
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Deactivation of the beta-catenin transactivating complex	Reactome	3	SOX3, SOX9, SRY	42	12	71.49	8.560e-6	2.947e-4
Glycoprotein hormones	Reactome	2	INHA, INHBB	12	12	166.81	6.007e-5	1.482e-3
Ovarian steroidogenesis	KEGG	2	CYP11A1, LHCGR	52	12	38.49	1.180e-3	1.534e-2
Cortisol synthesis and secretion	KEGG	2	NR5A1, CYP11A1	65	12	30.79	1.838e-3	2.141e-2
Antagonism of Activin by Follistatin	Reactome	1	INHBB	4	12	250.21	3.991e-3	3.767e-2
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	Reactome	1	CYP11A1	4	12	250.21	3.991e-3	3.767e-2
Cushing syndrome	KEGG	2	NR5A1, CYP11A1	155	12	12.91	1.003e-2	6.856e-2
Signaling by Activin	Reactome	1	INHBB	11	12	90.98	1.094e-2	7.246e-2
Transcriptional regulation by RUNX2	Reactome	1	SOX9	12	12	83.40	1.193e-2	7.605e-2
Hormone ligand-binding receptors	Reactome	1	LHCGR	12	12	83.40	1.193e-2	7.605e-2
Pregnenolone biosynthesis	Reactome	1	CYP11A1	12	12	83.40	1.193e-2	7.605e-2
Transcriptional regulation of pluripotent stem cells	Reactome	1	NR5A1	17	12	58.87	1.686e-2	9.366e-2
cAMP signaling pathway	KEGG	2	SOX9, LHCGR	226	12	8.86	2.055e-2	1.044e-1
Endogenous sterols	Reactome	1	CYP11A1	25	12	40.03	2.471e-2	1.156e-1
SUMOylation of intracellular receptors	Reactome	1	NR5A1	27	12	37.07	2.666e-2	1.207e-1