# GeDiPNet Cluster 181 -- Enriched Pathways -- generated 2026-10-07 23:56:44
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Regulation of gene expression by Hypoxia-inducible Factor	Reactome	3	EPO, VEGFA, HIF1A	11	40	81.89	5.544e-6	2.107e-4
Bile secretion	KEGG	5	SLC10A2, SLC51B, ABCC4, NR0B2, SLC51A	90	40	16.68	1.130e-5	3.777e-4
Platinum drug resistance	KEGG	4	BAD, CASP9, CYCS, ERCC1	75	40	16.01	1.081e-4	2.415e-3
Apoptosis - multiple species	KEGG	3	CASP9, CYCS, HTRA2	32	40	28.15	1.588e-4	3.281e-3
Formation of apoptosome	Reactome	2	CASP9, CYCS	6	40	100.08	1.609e-4	3.317e-3
Activation of caspases through apoptosome-mediated cleavage	Reactome	2	CASP9, CYCS	6	40	100.08	1.609e-4	3.317e-3
Detoxification of Reactive Oxygen Species	Reactome	3	SOD2, CYCS, SOD1	34	40	26.49	1.907e-4	3.811e-3
Kaposi sarcoma-associated herpesvirus infection	KEGG	5	VEGFA, HIF1A, C3, CASP9, CYCS	196	40	7.66	4.551e-4	7.575e-3
Regulation of the apoptosome activity	Reactome	2	CASP9, CYCS	10	40	60.05	4.786e-4	7.882e-3
Transcriptional activation of mitochondrial biogenesis	Reactome	3	IDH2, SOD2, CYCS	51	40	17.66	6.380e-4	9.845e-3
Thyroid hormone signaling pathway	KEGG	4	HIF1A, BAD, CASP9, NOTCH3	122	40	9.84	6.982e-4	1.055e-2
Legionellosis	KEGG	3	C3, CASP9, CYCS	56	40	16.08	8.396e-4	1.216e-2
Chemical carcinogenesis - reactive oxygen species	KEGG	5	SOD2, VEGFA, HIF1A, BAD, SOD1	227	40	6.61	8.857e-4	1.266e-2
Endometrial cancer	KEGG	3	BAD, CASP9, ILK	59	40	15.27	9.778e-4	1.368e-2
VEGF signaling pathway	KEGG	3	VEGFA, BAD, CASP9	60	40	15.01	1.027e-3	1.418e-2