# GeDiPNet Cluster 180 -- Enriched Pathways -- generated 2026-10-08 10:42:34
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Cocaine addiction	KEGG	5	GRM3, MAOB, GRIN2A, ADCY5, DRD2	49	57	21.50	3.274e-6	1.357e-4
Dopaminergic synapse	KEGG	6	COMT, DRD4, MAOB, GRIN2A, ADCY5, DRD2	132	57	9.58	3.605e-5	9.872e-4
Dopamine receptors	Reactome	2	DRD4, DRD2	5	57	84.28	2.193e-4	4.241e-3
PI3K events in ERBB4 signaling	Reactome	2	ERBB4, NRG1	10	57	42.14	9.719e-4	1.360e-2
Signaling by ERBB4	Reactome	2	ERBB4, NRG1	11	57	38.31	1.184e-3	1.578e-2
Pyrimidine catabolism	Reactome	2	DPYD, DPYS	11	57	38.31	1.184e-3	1.578e-2
ERBB2 Activates PTK6 Signaling	Reactome	2	ERBB4, NRG1	13	57	32.42	1.669e-3	2.043e-2
Neuroactive ligand-receptor interaction	KEGG	7	CHRM5, DRD4, GRM3, NPY5R, SCT, GRIN2A, DRD2	370	57	3.99	1.746e-3	2.112e-2
Alcoholism	KEGG	5	MAOB, NTRK2, GRIN2A, ADCY5, DRD2	188	57	5.60	1.931e-3	2.267e-2
SHC1 events in ERBB4 signaling	Reactome	2	ERBB4, NRG1	14	57	30.10	1.942e-3	2.277e-2
GRB2 events in ERBB2 signaling	Reactome	2	ERBB4, NRG1	14	57	30.10	1.942e-3	2.277e-2
Glutamatergic synapse	KEGG	4	GRM3, GRIN2A, SHANK3, ADCY5	116	57	7.27	2.200e-3	2.501e-2
ERBB2 Regulates Cell Motility	Reactome	2	ERBB4, NRG1	15	57	28.09	2.233e-3	2.531e-2
PI3K events in ERBB2 signaling	Reactome	2	ERBB4, NRG1	16	57	26.34	2.545e-3	2.785e-2
SHC1 events in ERBB2 signaling	Reactome	2	ERBB4, NRG1	17	57	24.79	2.875e-3	3.036e-2