# GeDiPNet Cluster 177 -- Enriched Pathways -- generated 2026-10-07 01:48:38
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Glucocorticoid biosynthesis	Reactome	2	CYP11B2, CYP11B1	10	2	1201.00	6.240e-7	3.233e-5
Endogenous sterols	Reactome	2	CYP11B2, CYP11B1	25	2	480.40	4.160e-6	1.631e-4
Steroid hormone biosynthesis	KEGG	2	CYP11B2, CYP11B1	63	2	190.63	2.708e-5	7.646e-4
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)	Reactome	1	CYP11B1	1	2	6005.00	1.665e-4	3.383e-3
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)	Reactome	1	CYP11B2	1	2	6005.00	1.665e-4	3.383e-3
Mineralocorticoid biosynthesis	Reactome	1	CYP11B2	6	2	1000.83	9.990e-4	1.354e-2
Cortisol synthesis and secretion	KEGG	1	CYP11B1	65	2	92.38	1.080e-2	7.190e-2
Aldosterone synthesis and secretion	KEGG	1	CYP11B2	98	2	61.28	1.625e-2	9.136e-2
Metabolic pathways	KEGG	2	CYP11B2, CYP11B1	1563	2	7.68	1.693e-2	9.384e-2
Cushing syndrome	KEGG	1	CYP11B1	155	2	38.74	2.565e-2	1.182e-1