# GeDiPNet Cluster 173 -- Enriched Pathways -- generated 2026-10-07 20:42:47
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
TRKA activation by NGF	Reactome	2	NGF, NTRK1	2	25	480.40	4.160e-6	1.631e-4
ARMS-mediated activation	Reactome	2	NGF, NTRK1	5	25	192.16	4.144e-5	1.097e-3
Sphingolipid de novo biosynthesis	Reactome	3	SPTLC1, SPTLC2, SPTLC3	43	25	33.52	9.307e-5	2.115e-3
PI3K/AKT activation	Reactome	2	NGF, NTRK1	9	25	106.76	1.484e-4	3.086e-3
Sphingolipid metabolism	KEGG	3	SPTLC1, SPTLC2, SPTLC3	54	25	26.69	1.843e-4	3.679e-3
Retrograde neurotrophin signalling	Reactome	2	NGF, NTRK1	11	25	87.35	2.262e-4	4.317e-3
Frs2-mediated activation	Reactome	2	NGF, NTRK1	12	25	80.07	2.711e-4	4.958e-3
Sphingolipid signaling pathway	KEGG	3	SPTLC1, SPTLC2, SPTLC3	122	25	11.81	1.998e-3	2.278e-2
Oligomerization of connexins into connexons	Reactome	1	GJB1	1	25	480.40	2.082e-3	2.349e-2
Phase 0 - rapid depolarisation	Reactome	2	SCN11A, SCN9A	44	25	21.84	3.730e-3	3.591e-2
NFG and proNGF binds to p75NTR	Reactome	1	NGF	2	25	240.20	4.159e-3	3.874e-2
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	Reactome	1	POMT1	3	25	160.13	6.232e-3	5.059e-2
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	Reactome	1	POMT1	3	25	160.13	6.232e-3	5.059e-2
SUMOylation of DNA methylation proteins	Reactome	1	DNMT1	4	25	120.10	8.301e-3	6.104e-2
Axonal growth stimulation	Reactome	1	NGF	4	25	120.10	8.301e-3	6.104e-2