# GeDiPNet Cluster 167 -- Enriched Pathways -- generated 2026-10-07 03:11:28
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Pancreatic cancer	KEGG	8	MAPK3, RPS6KB1, STAT3, JAK1, BRCA2, TP53, SMAD2, TGFB1	77	27	46.21	3.957e-12	7.640e-10
Proteoglycans in cancer	KEGG	10	MAPK3, RPS6KB1, STAT3, TP53, CASP3, HGF, MET, SMAD2, TGFB1, ITGB3	204	27	21.80	1.052e-11	1.874e-9
Pathways in cancer	KEGG	13	MAPK3, RPS6KB1, STAT3, JAK1, BRCA2, JAK2, TP53, CASP3, HGF, MET, SMAD2, TGFB1	533	27	10.85	2.540e-11	4.144e-9
Th17 cell differentiation	KEGG	8	AHR, MAPK3, STAT3, JAK1, JAK2, SMAD2, TGFB1, IL6ST	109	27	32.65	6.828e-11	1.016e-8
EGFR tyrosine kinase inhibitor resistance	KEGG	7	MAPK3, RPS6KB1, STAT3, JAK1, JAK2, HGF, MET	80	27	38.92	3.552e-10	4.514e-8
MAPK3 (ERK1) activation	Reactome	4	MAPK3, JAK1, JAK2, IL6ST	10	27	177.93	4.215e-9	4.065e-7
Interleukin-27 signaling	Reactome	4	STAT3, JAK1, JAK2, IL6ST	11	27	161.75	6.613e-9	6.096e-7
Interleukin-6 signaling	Reactome	4	STAT3, JAK1, JAK2, IL6ST	11	27	161.75	6.613e-9	6.096e-7
Interleukin-35 Signalling	Reactome	4	STAT3, JAK1, JAK2, IL6ST	12	27	148.27	9.904e-9	8.640e-7
MET activates STAT3	Reactome	3	STAT3, HGF, MET	3	27	444.81	1.013e-8	8.805e-7
Gastric cancer	KEGG	7	MAPK3, RPS6KB1, TP53, HGF, MET, SMAD2, TGFB1	150	27	20.76	2.967e-8	2.274e-6
Colorectal cancer	KEGG	6	MAPK3, RPS6KB1, TP53, CASP3, SMAD2, TGFB1	87	27	30.68	3.179e-8	2.412e-6
PI3K-Akt signaling pathway	KEGG	9	MAPK3, RPS6KB1, JAK1, BRCA1, JAK2, TP53, HGF, MET, ITGB3	361	27	11.09	5.266e-8	3.737e-6
Hepatitis B	KEGG	7	MAPK3, STAT3, JAK1, JAK2, TP53, CASP3, TGFB1	163	27	19.10	5.269e-8	3.738e-6
Hepatocellular carcinoma	KEGG	7	MAPK3, RPS6KB1, TP53, HGF, MET, SMAD2, TGFB1	170	27	18.32	7.038e-8	4.819e-6