# GeDiPNet Cluster 166 -- Enriched Pathways -- generated 2026-10-09 00:09:01
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Voltage gated Potassium channels	Reactome	2	KCNQ2, KCNQ3	43	12	46.55	8.078e-4	1.140e-2
Phase 0 - rapid depolarisation	Reactome	2	SCN2A, SCN8A	44	12	45.49	8.458e-4	1.173e-2
Thyroid hormone synthesis	KEGG	2	ATP1A2, CGA	75	12	26.69	2.439e-3	2.638e-2
Cholinergic synapse	KEGG	2	KCNQ2, KCNQ3	115	12	17.41	5.634e-3	4.746e-2
Mineralocorticoid biosynthesis	Reactome	1	CGA	6	12	166.81	5.981e-3	4.934e-2
Thyroxine biosynthesis	Reactome	1	CGA	7	12	142.98	6.975e-3	5.461e-2
Highly calcium permeable nicotinic acetylcholine receptors	Reactome	1	CHRNA2	9	12	111.20	8.960e-3	6.459e-2
Reactions specific to the complex N-glycan synthesis pathway	Reactome	1	CGA	10	12	100.08	9.951e-3	6.891e-2
Androgen biosynthesis	Reactome	1	CGA	11	12	90.98	1.094e-2	7.338e-2
Glycoprotein hormones	Reactome	1	CGA	12	12	83.40	1.193e-2	7.721e-2
Hormone ligand-binding receptors	Reactome	1	CGA	12	12	83.40	1.193e-2	7.721e-2
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	Reactome	1	CHRNA2	12	12	83.40	1.193e-2	7.721e-2
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	Reactome	1	CGA	15	12	66.72	1.489e-2	8.817e-2
cAMP signaling pathway	KEGG	2	ATP1A2, CGA	226	12	8.86	2.055e-2	1.068e-1
Proximal tubule bicarbonate reclamation	KEGG	1	ATP1A2	23	12	43.51	2.275e-2	1.128e-1