# GeDiPNet Cluster 160 -- Enriched Pathways -- generated 2026-10-08 06:32:47
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Pathways in cancer	KEGG	11	FAS, JAK2, APC, BDKRB1, FLT3, KRAS, MECOM, NFE2L2, NOTCH1, NRAS, STAT5B	533	32	7.75	6.551e-8	4.517e-6
FLT3 Signaling	Reactome	3	FLT3, KRAS, NRAS	7	32	160.85	5.971e-7	3.113e-5
Signaling by SCF-KIT	Reactome	4	JAK2, KRAS, NRAS, STAT5B	37	32	40.57	2.577e-6	1.107e-4
Alzheimer disease	KEGG	8	FAS, MAPT, APC, APOE, APP, KRAS, NRAS, PSEN1	388	32	7.74	5.878e-6	2.205e-4
Chemical carcinogenesis - receptor activation	KEGG	6	JAK2, AHR, CYP1A2, KRAS, NRAS, STAT5B	215	32	10.47	1.885e-5	5.815e-4
RAS GTPase cycle mutants	Reactome	2	KRAS, NRAS	3	32	250.21	2.060e-5	6.257e-4
Acute myeloid leukemia	KEGG	4	FLT3, KRAS, NRAS, STAT5B	68	32	22.08	2.999e-5	8.483e-4
Prolactin signaling pathway	KEGG	4	JAK2, KRAS, NRAS, STAT5B	71	32	21.14	3.558e-5	9.781e-4
Chronic myeloid leukemia	KEGG	4	KRAS, MECOM, NRAS, STAT5B	77	32	19.50	4.901e-5	1.273e-3
Hepatitis C	KEGG	5	FAS, EIF2AK1, KRAS, NRAS, OCLN	159	32	11.80	5.760e-5	1.450e-3
Downstream signal transduction	Reactome	3	KRAS, NRAS, STAT5B	29	32	38.83	5.990e-5	1.497e-3
Hepatitis B	KEGG	5	FAS, JAK2, KRAS, NRAS, STAT5B	163	32	11.51	6.484e-5	1.595e-3
Activation of RAS in B cells	Reactome	2	KRAS, NRAS	5	32	150.13	6.844e-5	1.666e-3
RAF activation	Reactome	3	JAK2, KRAS, NRAS	32	32	35.19	8.087e-5	1.908e-3
Estrogen-stimulated signaling through PRKCZ	Reactome	2	KRAS, NRAS	6	32	125.10	1.025e-4	2.320e-3