# GeDiPNet Cluster 16 -- Enriched Pathways -- generated 2026-10-08 07:10:52
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Factors involved in megakaryocyte development and platelet production	Reactome	4	HBB, HBG2, HBD, HBG1	99	11	44.11	1.371e-6	6.410e-5
Malaria	KEGG	2	HBB, TGFB2	50	11	43.67	9.121e-4	1.296e-2
Adrenaline signalling through Alpha-2 adrenergic receptor	Reactome	1	ADRA2B	3	11	363.94	2.745e-3	2.946e-2
Vitamin C (ascorbate) metabolism	Reactome	1	CYB5R3	8	11	136.48	7.306e-3	5.740e-2
Adrenoceptors	Reactome	1	ADRA2B	9	11	121.31	8.216e-3	6.202e-2
Erythrocytes take up oxygen and release carbon dioxide	Reactome	1	HBB	9	11	121.31	8.216e-3	6.202e-2
Scavenging of heme from plasma	Reactome	1	HBB	13	11	83.99	1.185e-2	7.772e-2
Erythrocytes take up carbon dioxide and release oxygen	Reactome	1	HBB	13	11	83.99	1.185e-2	7.772e-2
Biosynthesis of various nucleotide sugars	KEGG	1	CYB5R3	15	11	72.79	1.366e-2	8.453e-2
mRNA decay by 3' to 5' exoribonuclease	Reactome	1	HBS1L	16	11	68.24	1.456e-2	8.790e-2
Phase I - Functionalization of compounds	Reactome	1	CYB5R3	21	11	51.99	1.907e-2	1.033e-1
G alpha (z) signalling events	Reactome	1	ADRA2B	33	11	33.09	2.983e-2	1.320e-1
African trypanosomiasis	KEGG	1	HBB	37	11	29.51	3.338e-2	1.404e-1
Molecules associated with elastic fibres	Reactome	1	TGFB2	38	11	28.73	3.427e-2	1.424e-1
Legionellosis	KEGG	1	HBS1L	56	11	19.50	5.013e-2	1.746e-1