# GeDiPNet Cluster 159 -- Enriched Pathways -- generated 2026-10-08 06:32:25
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Thyroid cancer	KEGG	3	RET, BRAF, CCDC6	37	34	28.64	1.508e-4	3.149e-3
ECM-receptor interaction	KEGG	3	ITGA8, FRAS1, NPNT	89	34	11.91	1.994e-3	2.322e-2
RAF activation	Reactome	2	BRAF, PPP2R5C	32	34	22.08	3.659e-3	3.598e-2
RAF/MAP kinase cascade	Reactome	3	FGF20, RET, GFRA1	124	34	8.55	5.090e-3	4.507e-2
Negative regulation of MAPK pathway	Reactome	2	BRAF, PPP2R5C	38	34	18.59	5.131e-3	4.529e-2
RET signaling	Reactome	2	RET, GFRA1	40	34	17.66	5.673e-3	4.855e-2
Breast cancer	KEGG	3	FGF20, WNT9B, BRAF	148	34	7.16	8.297e-3	6.227e-2
Regulation of thyroid hormone activity	Reactome	1	DIO3	3	34	117.75	8.470e-3	6.313e-2
Regulation of commissural axon pathfinding by SLIT and ROBO	Reactome	1	ROBO1	3	34	117.75	8.470e-3	6.313e-2
Gastric cancer	KEGG	3	FGF20, WNT9B, BRAF	150	34	7.06	8.608e-3	6.390e-2
Regulation of PTEN gene transcription	Reactome	2	SNAI1, SNAI2	53	34	13.33	9.794e-3	6.917e-2
Biosynthesis of D-series resolvins	Reactome	1	HPGD	4	34	88.31	1.128e-2	7.536e-2
Role of ABL in ROBO-SLIT signaling	Reactome	1	ROBO1	4	34	88.31	1.128e-2	7.536e-2
SLIT2:ROBO1 increases RHOA activity	Reactome	1	ROBO1	4	34	88.31	1.128e-2	7.536e-2
Synthesis of Lipoxins (LX)	Reactome	1	HPGD	5	34	70.65	1.408e-2	8.603e-2