# GeDiPNet Cluster 158 -- Enriched Pathways -- generated 2026-10-10 14:43:07
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Inhibition of Signaling by Overexpressed EGFR	Reactome	3	BTC, AREG, EREG	8	46	97.91	2.906e-6	1.302e-4
EGFR interacts with phospholipase C-gamma	Reactome	3	BTC, AREG, EREG	9	46	87.03	4.347e-6	1.813e-4
Signaling by EGFR	Reactome	3	BTC, AREG, EREG	11	46	71.21	8.493e-6	3.115e-4
GRB2 events in EGFR signaling	Reactome	3	BTC, AREG, EREG	13	46	60.25	1.464e-5	4.861e-4
SHC1 events in EGFR signaling	Reactome	3	BTC, AREG, EREG	14	46	55.95	1.858e-5	5.924e-4
GAB1 signalosome	Reactome	3	BTC, AREG, EREG	17	46	46.07	3.444e-5	9.843e-4
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Reactome	3	BTC, AREG, EREG	23	46	34.05	8.826e-5	2.098e-3
EGFR downregulation	Reactome	3	BTC, AREG, EREG	31	46	25.27	2.193e-4	4.302e-3
ErbB signaling pathway	KEGG	4	BTC, CBLB, AREG, EREG	86	46	12.14	3.180e-4	5.783e-3
ATF6 (ATF6-alpha) activates chaperone genes	Reactome	2	ATF6, CALR	9	46	58.02	5.079e-4	8.371e-3
PI3K events in ERBB4 signaling	Reactome	2	BTC, EREG	10	46	52.22	6.333e-4	9.928e-3
Mitochondrial iron-sulfur cluster biogenesis	Reactome	2	GLRX5, HSCB	10	46	52.22	6.333e-4	9.928e-3
Signaling by ERBB4	Reactome	2	BTC, EREG	11	46	47.47	7.722e-4	1.155e-2
ERBB2 Activates PTK6 Signaling	Reactome	2	BTC, EREG	13	46	40.17	1.090e-3	1.504e-2
SHC1 events in ERBB4 signaling	Reactome	2	BTC, EREG	14	46	37.30	1.268e-3	1.686e-2