# GeDiPNet Cluster 151 -- Enriched Pathways -- generated 2026-10-07 15:34:55
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Noncanonical activation of NOTCH3	Reactome	3	NCSTN, PSENEN, PSEN1	8	6	750.63	3.877e-9	3.769e-7
Regulated proteolysis of p75NTR	Reactome	3	NCSTN, PSENEN, PSEN1	11	6	545.91	1.142e-8	9.789e-7
NRIF signals cell death from the nucleus	Reactome	3	NCSTN, PSENEN, PSEN1	15	6	400.33	3.146e-8	2.389e-6
NOTCH3 Activation and Transmission of Signal to the Nucleus	Reactome	3	NCSTN, PSENEN, PSEN1	19	6	316.05	6.694e-8	4.624e-6
Amyloid fiber formation	Reactome	4	APP, NCSTN, PSENEN, TTR	109	6	73.46	9.497e-8	6.254e-6
Nuclear signaling by ERBB4	Reactome	3	NCSTN, PSENEN, PSEN1	24	6	250.21	1.397e-7	8.741e-6
EPH-ephrin mediated repulsion of cells	Reactome	3	NCSTN, PSENEN, PSEN1	50	6	120.10	1.346e-6	6.324e-5
Constitutive Signaling by NOTCH1 PEST Domain Mutants	Reactome	3	NCSTN, PSENEN, PSEN1	58	6	103.53	2.116e-6	9.216e-5
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Reactome	3	NCSTN, PSENEN, PSEN1	58	6	103.53	2.116e-6	9.216e-5
Notch signaling pathway	KEGG	3	NCSTN, PSENEN, PSEN1	62	6	96.85	2.592e-6	1.102e-4
Alzheimer disease	KEGG	4	APP, NCSTN, PSENEN, PSEN1	388	6	20.64	1.528e-5	4.778e-4
Pathways of neurodegeneration - multiple diseases	KEGG	3	APP, PSEN1, LRRK2	480	6	12.51	1.159e-3	1.517e-2
Neutrophil degranulation	Reactome	3	NCSTN, PSEN1, TTR	480	6	12.51	1.159e-3	1.517e-2
PTK6 promotes HIF1A stabilization	Reactome	1	LRRK2	6	6	333.61	2.994e-3	3.068e-2
Advanced glycosylation endproduct receptor signaling	Reactome	1	APP	8	6	250.21	3.991e-3	3.767e-2