# GeDiPNet Cluster 15 -- Enriched Pathways -- generated 2026-10-07 04:02:21
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Interleukin-1 processing	Reactome	3	IL1A, IL18, IL1B	8	48	93.83	3.309e-6	1.347e-4
Interleukin-4 and Interleukin-13 signaling	Reactome	6	BCL2, IL1A, IL18, IL1B, POMC, HIF1A	108	48	13.90	4.152e-6	1.630e-4
Purinergic signaling in leishmaniasis infection	Reactome	3	IL1A, IL18, IL1B	24	48	31.28	1.143e-4	2.495e-3
Central carbon metabolism in cancer	KEGG	4	PDGFRA, HIF1A, IDH1, IDH2	71	48	14.10	1.793e-4	3.594e-3
Cellular senescence	KEGG	5	TRPV4, IL1A, CDKN2A, HLA-B, IGFBP3	157	48	7.97	3.897e-4	6.583e-3
Type I diabetes mellitus	KEGG	3	IL1A, IL1B, HLA-B	44	48	17.06	7.073e-4	1.045e-2
Graft-versus-host disease	KEGG	3	IL1A, IL1B, HLA-B	45	48	16.68	7.557e-4	1.100e-2
Interleukin-10 signaling	Reactome	3	IL1A, IL18, IL1B	47	48	15.97	8.587e-4	1.209e-2
Human cytomegalovirus infection	KEGG	5	PDGFRA, IL1B, CDKN2A, CREB5, HLA-B	226	48	5.54	2.000e-3	2.280e-2
Inflammatory bowel disease	KEGG	3	IL1A, IL18, IL1B	66	48	11.37	2.298e-3	2.528e-2
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Reactome	3	PSMC3, HIF1A, VHL	66	48	11.37	2.298e-3	2.528e-2
Fluid shear stress and atherosclerosis	KEGG	4	TRPV4, BCL2, IL1A, IL1B	141	48	7.10	2.373e-3	2.588e-2
Renal cell carcinoma	KEGG	3	HIF1A, PTPN11, VHL	70	48	10.72	2.718e-3	2.869e-2
Biosynthesis of amino acids	KEGG	3	IDH1, IDH2, PYCR3	75	48	10.01	3.307e-3	3.301e-2
p53 signaling pathway	KEGG	3	BCL2, CDKN2A, IGFBP3	75	48	10.01	3.307e-3	3.301e-2