# GeDiPNet Cluster 147 -- Enriched Pathways -- generated 2026-10-08 07:08:55
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Pathways in cancer	KEGG	23	DAPK1, DCC, BCL2, EGFR, ERBB2, KEAP1, KRAS, TP53, AKT1, CCND1, HIF1A, HMOX1	533	81	6.40	4.133e-13	8.956e-11
Gastric cancer	KEGG	14	ABCB1, BCL2, EGFR, ERBB2, KRAS, TP53, AKT1, CCND1, PIK3CA, TCF7L2, TGFB1, FGF5	150	81	13.84	1.082e-12	2.187e-10
Prostate cancer	KEGG	12	BCL2, EGFR, ERBB2, KRAS, TP53, AKT1, CCND1, MMP9, PIK3CA, TCF7L2, LEF1, INS	98	81	18.16	1.942e-12	3.755e-10
Colorectal cancer	KEGG	11	DCC, BCL2, EGFR, KRAS, TP53, AKT1, CCND1, PIK3CA, TCF7L2, TGFB1, LEF1	87	81	18.75	1.207e-11	2.034e-9
Hepatocellular carcinoma	KEGG	13	EGFR, KEAP1, KRAS, TP53, AKT1, CCND1, HMOX1, NFE2L2, PIK3CA, TCF7L2, TGFB1, LEF1	170	81	11.34	9.409e-11	1.297e-8
Interleukin-4 and Interleukin-13 signaling	Reactome	11	BCL2, TP53, AKT1, CCND1, HIF1A, HMOX1, IL13, MMP9, PTGS2, TGFB1, POMC	108	81	15.10	1.328e-10	1.767e-8
Endometrial cancer	KEGG	9	EGFR, ERBB2, KRAS, TP53, AKT1, CCND1, PIK3CA, TCF7L2, LEF1	59	81	22.62	1.751e-10	2.275e-8
Proteoglycans in cancer	KEGG	13	EGFR, ERBB2, ERBB3, ERBB4, KRAS, TP53, AKT1, CCND1, HIF1A, MMP9, PIK3CA, TGFB1	204	81	9.45	9.101e-10	9.833e-8
Breast cancer	KEGG	11	EGFR, ERBB2, KRAS, TP53, AKT1, CCND1, PIK3CA, TCF7L2, FGF5, LEF1, WNT2B	148	81	11.02	3.966e-9	3.739e-7
Bladder cancer	KEGG	7	DAPK1, EGFR, ERBB2, KRAS, TP53, CCND1, MMP9	41	81	25.31	9.112e-9	7.789e-7
Signaling by ERBB2 KD Mutants	Reactome	6	EGFR, ERBB2, ERBB3, ERBB4, KRAS, PIK3CA	25	81	35.59	1.247e-8	1.028e-6
Endocrine resistance	KEGG	9	BCL2, EGFR, ERBB2, KRAS, TP53, AKT1, CCND1, MMP9, PIK3CA	99	81	13.48	1.941e-8	1.529e-6
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Reactome	9	PPP2R5E, EGFR, ERBB2, ERBB3, ERBB4, AKT1, PIK3CA, FGF5, INS	103	81	12.96	2.754e-8	2.085e-6
Pancreatic cancer	KEGG	8	EGFR, ERBB2, KRAS, TP53, AKT1, CCND1, PIK3CA, TGFB1	77	81	15.40	4.347e-8	3.120e-6
PI3K events in ERBB2 signaling	Reactome	5	EGFR, ERBB2, ERBB3, ERBB4, PIK3CA	16	81	46.33	5.075e-8	3.589e-6