# GeDiPNet Cluster 142 -- Enriched Pathways -- generated 2026-10-07 20:45:32
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Interleukin-4 and Interleukin-13 signaling	Reactome	4	FGF2, ITGB2, MMP9, POMC	108	19	23.41	2.160e-5	6.367e-4
PI3K-Akt signaling pathway	KEGG	5	FGF2, LAMA3, NGF, BDNF, NTF3	361	19	8.75	1.959e-4	3.847e-3
Ras signaling pathway	KEGG	4	FGF2, NGF, BDNF, NTF3	237	19	10.67	4.538e-4	7.392e-3
Endocrine resistance	KEGG	3	MMP9, CYP2D6, HBEGF	99	19	19.15	4.784e-4	7.705e-3
Neurotrophin signaling pathway	KEGG	3	NGF, BDNF, NTF3	120	19	15.80	8.387e-4	1.187e-2
MAPK signaling pathway	KEGG	4	FGF2, NGF, BDNF, NTF3	299	19	8.46	1.086e-3	1.443e-2
Estrogen signaling pathway	KEGG	3	MMP9, HBEGF, POMC	139	19	13.64	1.283e-3	1.635e-2
Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)	Reactome	1	SLC35C1	1	19	632.11	1.582e-3	1.922e-2
Bladder cancer	KEGG	2	MMP9, HBEGF	41	19	30.83	1.874e-3	2.173e-2
Assembly of collagen fibrils and other multimeric structures	Reactome	2	LAMA3, MMP9	51	19	24.79	2.887e-3	2.997e-2
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)	Reactome	1	POMC	2	19	316.05	3.162e-3	3.196e-2
TRKA activation by NGF	Reactome	1	NGF	2	19	316.05	3.162e-3	3.196e-2
NFG and proNGF binds to p75NTR	Reactome	1	NGF	2	19	316.05	3.162e-3	3.196e-2
NTF3 activates NTRK3 signaling	Reactome	1	NTF3	2	19	316.05	3.162e-3	3.196e-2
Peptide hormone biosynthesis	Reactome	1	POMC	2	19	316.05	3.162e-3	3.196e-2