# GeDiPNet Cluster 141 -- Pairs Within Cluster -- generated 2026-10-07 14:25:07
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected across all tested pairs. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 17:17:47.
Disease A	Disease B	Similarity Score	Shared Genes	P-value	FDR Q-value
Peroxisome biogenesis disorder	Zellweger spectrum disorder	0.52000	13	5.711e-39	2.324e-37
Heimler syndrome	Peroxisome biogenesis disorder	0.16000	4	4.538e-12	5.157e-11
Heimler syndrome	Zellweger spectrum disorder	0.20000	3	1.880e-9	1.658e-8
Deafness enamel hypoplasia nail defects	Deafness-enamel hypoplasia-nail defects syndrome	0.66667	2	8.436e-9	6.837e-8
Deafness enamel hypoplasia nail defects	Heimler syndrome	0.40000	2	5.062e-8	3.718e-7
Deafness-enamel hypoplasia-nail defects syndrome	Heimler syndrome	0.40000	2	5.062e-8	3.718e-7
Deafness-enamel hypoplasia-nail defects syndrome	Zellweger spectrum disorder	0.14286	2	6.580e-7	4.002e-6
Deafness enamel hypoplasia nail defects	Zellweger spectrum disorder	0.14286	2	6.580e-7	4.002e-6
Deafness-enamel hypoplasia-nail defects syndrome	Peroxisome biogenesis disorder	0.08000	2	2.328e-6	1.281e-5
Deafness enamel hypoplasia nail defects	Peroxisome biogenesis disorder	0.08000	2	2.328e-6	1.281e-5
Deafness enamel hypoplasia nail defects	Spinocerebellar ataxia blindness deafness syndrome	0.33333	1	1.299e-4	3.908e-4
Deafness enamel hypoplasia nail defects	peroxisome biogenesis disorder due to PEX1 defect	0.33333	1	1.299e-4	3.908e-4
Deafness-enamel hypoplasia-nail defects syndrome	Spinocerebellar ataxia blindness deafness syndrome	0.33333	1	1.299e-4	3.908e-4
Deafness-enamel hypoplasia-nail defects syndrome	peroxisome biogenesis disorder due to PEX1 defect	0.33333	1	1.299e-4	3.908e-4
dilated cardiomyopathy 2B	Heimler syndrome	0.20000	1	2.598e-4	6.484e-4
Heimler syndrome	peroxisome biogenesis disorder due to PEX1 defect	0.20000	1	2.598e-4	6.484e-4
Heimler syndrome	Spinocerebellar ataxia blindness deafness syndrome	0.20000	1	2.598e-4	6.484e-4
Central nervous system demyelinating disease	Spinocerebellar ataxia blindness deafness syndrome	0.20000	1	2.598e-4	6.484e-4
Central nervous system demyelinating disease	megalencephalic leukoencephalopathy with subcortical cysts 1	0.20000	1	2.598e-4	6.484e-4
Central nervous system demyelinating disease	Deafness-enamel hypoplasia-nail defects syndrome	0.16667	1	5.195e-4	1.058e-3
Central nervous system demyelinating disease	Deafness enamel hypoplasia nail defects	0.16667	1	5.195e-4	1.058e-3
Spinocerebellar ataxia blindness deafness syndrome	Zellweger spectrum disorder	0.07143	1	8.443e-4	1.497e-3
dilated cardiomyopathy 2B	Peroxisome biogenesis disorder	0.04000	1	1.559e-3	2.374e-3