# GeDiPNet Cluster 14 -- Enriched Pathways -- generated 2026-10-09 05:03:27
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
N-Glycan biosynthesis	KEGG	30	ALG11, ALG12, ALG1, ALG2, ALG3, ALG6, ALG8, ALG9, B4GALT1, ALG10, ALG13, ALG14	55	99	66.17	6.234e-50	8.648e-46
Various types of N-glycan biosynthesis	KEGG	19	ALG11, ALG12, ALG1, ALG2, ALG3, ALG9, B4GALT1, ALG13, ALG14, DDOST, MAGT1, MAN2A2	43	99	53.60	2.800e-29	6.905e-26
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Reactome	11	ALG12, ALG1, ALG2, ALG3, ALG6, ALG8, ALG9, ALG13, ALG14, MPDU1, DPAGT1	11	99	121.31	6.741e-24	9.123e-21
Metabolic pathways	KEGG	44	A4GALT, ALG11, ALG12, ALG1, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B4GALT1, ALG10	1563	99	3.42	1.200e-14	3.328e-12
Intra-Golgi traffic	Reactome	10	COG1, COG2, COG4, COG5, COG6, COG7, COG8, COG3, MAN2A2, STX5	44	99	27.57	1.792e-12	3.422e-10
Retrograde transport at the Trans-Golgi-Network	Reactome	8	COG1, COG2, COG4, COG5, COG6, COG7, COG8, COG3	46	99	21.10	3.226e-9	3.047e-7
Protein processing in endoplasmic reticulum	KEGG	12	DDOST, MAGT1, SSR3, SSR4, TUSC3, STT3A, STT3B, EDEM3, MOGS, RPN2, UGGT1, MAN1B1	171	99	8.51	1.490e-8	1.168e-6
Asparagine N-linked glycosylation	Reactome	5	DDOST, MAGT1, TUSC3, STT3A, RPN2	11	99	55.14	1.527e-8	1.194e-6
Synthesis of Dolichyl-phosphate	Reactome	4	SRD5A3, NUS1, DHDDS, DOLK	6	99	80.88	6.435e-8	4.315e-6
COPI-mediated anterograde transport	Reactome	9	COG1, COG2, COG4, COG5, COG6, COG7, COG8, COG3, STX5	101	99	10.81	1.357e-7	8.279e-6
Synthesis of glycosylphosphatidylinositol (GPI)	Reactome	5	DPM2, PIGF, PIGM, PIGC, PIGW	17	99	35.68	1.967e-7	1.133e-5
Synthesis of dolichyl-phosphate mannose	Reactome	3	DPM2, DPM1, DPM3	3	99	121.31	5.434e-7	2.746e-5
Defective DPM1 causes DPM1-CDG (CDG-1e)	Reactome	3	DPM2, DPM1, DPM3	3	99	121.31	5.434e-7	2.746e-5
Defective DPM3 causes DPM3-CDG (CDG-1o)	Reactome	3	DPM2, DPM1, DPM3	3	99	121.31	5.434e-7	2.746e-5
Defective DPM2 causes DPM2-CDG (CDG-1u)	Reactome	3	DPM2, DPM1, DPM3	3	99	121.31	5.434e-7	2.746e-5