# GeDiPNet Cluster 139 -- Enriched Pathways -- generated 2026-10-10 09:22:03
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
AGE-RAGE signaling pathway in diabetic complications	KEGG	44	AGER, AGTR1, CCL2, EDN1, NOS3, SELE, SERPINE1, TNF, VEGFA, CXCL8, NFATC1, PLCB1	101	1078	4.85	2.177e-20	1.636e-17
Lipid and atherosclerosis	KEGG	62	ABCA1, AGER, APOA1, APOB, CCL2, CD40LG, CYBA, HSPD1, IRAK1, LDLR, MMP1, MMP3	216	1078	3.20	3.346e-17	1.596e-14
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Reactome	44	AHSG, APOA1, APOA5, APOB, APOE, F2, MIA3, MMP1, PAPPA, APOL1, CST3, PLG	125	1078	3.92	3.638e-16	1.445e-13
Complement and coagulation cascades	KEGG	35	F2, F7, FGB, PROCR, SERPINE1, PLG, CFH, CFHR1, CFHR5, F11, F5, FGA	88	1078	4.43	5.288e-15	1.714e-12
Interleukin-4 and Interleukin-13 signaling	Reactome	39	CCL2, HMOX1, IL10, MMP1, MMP3, MMP9, PTGS2, TNF, TP53, TWIST1, VEGFA, CXCL8	108	1078	4.02	6.647e-15	2.130e-12
Platelet degranulation 	Reactome	41	AHSG, APOA1, FGB, PECAM1, SERPINE1, VEGFA, CALM2, PLG, ACTN4, FN1, ACTN2, F5	123	1078	3.71	3.193e-14	8.942e-12
Post-translational protein phosphorylation	Reactome	38	AHSG, APOA1, APOA5, APOB, APOE, MIA3, APOL1, CST3, SCG2, FN1, F5, FGA	108	1078	3.92	3.900e-14	1.068e-11
Pathways in cancer	KEGG	102	AGTR1, CDKN2B, CXCL12, EDN1, EPO, ESR1, ESR2, F2, GNB3, GSTM1, GSTT1, HMOX1	533	1078	2.13	6.355e-14	1.655e-11
Malaria	KEGG	23	CCL2, CD40LG, IL10, PECAM1, SELE, TLR4, TNF, CXCL8, HBB, TGFB1, CSF3, IFNG	50	1078	5.12	6.744e-12	1.260e-9
Cholesterol metabolism	KEGG	23	ABCA1, ABCG5, ABCG8, ANGPTL4, APOA1, APOB, APOC3, APOE, LDLR, LIPA, LIPC, LIPG	51	1078	5.02	1.125e-11	2.014e-9
HIF-1 signaling pathway	KEGG	34	EDN1, EPO, HMOX1, NOS3, NPPA, SERPINE1, TLR4, VEGFA, MKNK1, IL6R, PLCG2, TIMP1	110	1078	3.44	5.394e-11	8.317e-9
Chagas disease	KEGG	32	ACE, CCL2, IL10, IRAK1, SERPINE1, TLR4, TNF, TRAF6, CXCL8, PLCB1, PLCB2, TGFB1	103	1078	3.46	1.713e-10	2.399e-8
African trypanosomiasis	KEGG	18	APOA1, IL10, NPPA, SELE, TNF, APOL1, HBB, PLCB1, PLCB2, FAS, IFNG, IL6	37	1078	5.42	4.225e-10	5.375e-8
Fluid shear stress and atherosclerosis	KEGG	36	CCL2, CYBA, EDN1, GSTM1, GSTT1, HMOX1, MMP9, NOS3, PECAM1, SELE, TNF, TP53	141	1078	2.84	5.205e-9	5.185e-7
Leishmaniasis	KEGG	25	CYBA, FCGR2A, FCGR3A, IL10, IRAK1, PTGS2, TLR4, TNF, TRAF6, TGFB1, NCF4, CYBB	78	1078	3.57	8.335e-9	7.833e-7