# GeDiPNet Cluster 133 -- Enriched Pathways -- generated 2026-10-09 23:46:28
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Motor proteins	KEGG	4	DNAH10, DNAH8, DNAH1, DNAH7	194	22	11.26	3.844e-4	6.737e-3
Huntington disease	KEGG	4	DNAH10, DNAH8, DNAH1, DNAH7	308	22	7.09	2.153e-3	2.504e-2
Amyotrophic lateral sclerosis	KEGG	4	DNAH10, DNAH8, DNAH1, DNAH7	368	22	5.93	4.095e-3	3.943e-2
Pathways of neurodegeneration - multiple diseases	KEGG	4	DNAH10, DNAH8, DNAH1, DNAH7	480	22	4.55	1.039e-2	7.273e-2
Processing of SMDT1	Reactome	1	PMPCA	16	22	34.12	2.893e-2	1.313e-1
Transcriptional activation of mitochondrial biogenesis	Reactome	1	TWNK	51	22	10.70	8.945e-2	2.398e-1
Intraflagellar transport	Reactome	1	IFT74	54	22	10.11	9.446e-2	2.470e-1
Lysine degradation	KEGG	1	KMT2A	63	22	8.67	1.094e-1	2.668e-1
RUNX1 regulates transcription of genes involved in differentiation of HSCs	Reactome	1	KMT2A	69	22	7.91	1.192e-1	2.796e-1
PKMTs methylate histone lysines	Reactome	1	KMT2A	71	22	7.69	1.224e-1	2.838e-1
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Reactome	1	KMT2A	97	22	5.63	1.635e-1	3.319e-1
Spinocerebellar ataxia	KEGG	1	TWNK	144	22	3.79	2.333e-1	4.062e-1
Cushing syndrome	KEGG	1	KMT2A	155	22	3.52	2.488e-1	4.207e-1
Transcriptional misregulation in cancer	KEGG	1	KMT2A	198	22	2.76	3.065e-1	4.767e-1
Metabolic pathways	KEGG	1	KMT2A	1563	22	0.35	9.536e-1	9.976e-1