# GeDiPNet Cluster 131 -- Enriched Pathways -- generated 2026-10-07 20:44:02
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Cytoskeleton in muscle cells	KEGG	36	CAPN3, DAG1, SGCA, SGCB, SGCD, SGCG, TCAP, TTN, PLEC, LAMA2, LMNA, COL6A1	232	179	10.41	9.151e-27	2.063e-23
Dilated cardiomyopathy	KEGG	17	CAV3, DAG1, SGCA, SGCB, SGCD, SGCG, TTN, LAMA2, LMNA, DES, DMD, ADCY2	105	179	10.86	2.156e-13	5.177e-11
Hypertrophic cardiomyopathy	KEGG	16	CAV3, DAG1, SGCA, SGCB, SGCD, SGCG, TTN, LAMA2, LMNA, DES, DMD, EMD	99	179	10.84	1.164e-12	2.518e-10
Striated Muscle Contraction	Reactome	11	TCAP, TTN, DES, DMD, NEB, ACTA1, TNNI2, TNNT1, TPM3, ACTN2, MYH8	36	179	20.50	2.575e-12	5.218e-10
Arrhythmogenic right ventricular cardiomyopathy	KEGG	13	CAV3, DAG1, SGCA, SGCB, SGCD, SGCG, LAMA2, LMNA, DES, DMD, EMD, ITGA7	86	179	10.14	3.905e-10	4.879e-8
Mannose type O-glycan biosynthesis	KEGG	8	CRPPA, FKRP, POMT1, FKTN, POMT2, POMGNT1, POMK, LARGE1	23	179	23.34	8.435e-10	9.634e-8
O-linked glycosylation	Reactome	6	DAG1, POMT1, POMT2, POMGNT1, POMK, LARGE1	10	179	40.26	2.015e-9	2.064e-7
Viral myocarditis	KEGG	9	CAV3, DAG1, SGCA, SGCB, SGCD, SGCG, LAMA2, DMD, MYH7	70	179	8.63	8.834e-7	4.379e-5
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	Reactome	3	DAG1, POMT1, POMT2	3	179	67.09	3.256e-6	1.330e-4
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	Reactome	3	DAG1, POMT1, POMT2	3	179	67.09	3.256e-6	1.330e-4
Assembly of collagen fibrils and other multimeric structures	Reactome	6	PLEC, COL6A1, COL6A2, COL6A3, COL6A6, CTSB	51	179	7.89	1.041e-4	2.327e-3
ECM proteoglycans	Reactome	6	DAG1, COL6A1, COL6A2, COL6A3, COL6A6, ITGA7	51	179	7.89	1.041e-4	2.327e-3
Motor proteins	KEGG	11	MYH2, ACTA1, DYNC1H1, MYH7, TNNI2, TNNT1, TPM3, TUBG1, MYH8, MYO7B, TUBA1B	194	179	3.80	1.539e-4	3.177e-3
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	Reactome	2	DAG1, POMGNT1	2	179	67.09	2.209e-4	4.235e-3
NCAM1 interactions	Reactome	4	COL6A1, COL6A2, COL6A3, COL6A6	21	179	12.78	2.342e-4	4.429e-3