# GeDiPNet Cluster 127 -- Top Shared Genes -- generated 2026-10-07 05:28:07
# Curated genes (disease_gdp) linked to 2 or more of this cluster's member diseases, most widely shared first. Data as of: 2026-10-07 03:15:01.
Gene	Member Diseases Linked	Cluster Size	Linked Diseases
P4HB	6	10	Bone fragility with contractures, arterial rupture, and deafness; Cole-carpenter syndrome; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis; Osteoporosis-pseudoglioma syndrome
B4GALT7	5	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; ehlers-danlos syndrome, spondylodysplastic type, 1; Larsen syndrome; Osteoporosis-pseudoglioma syndrome
COL1A1	5	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis; Osteoporosis-pseudoglioma syndrome
COL1A2	5	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis; Osteoporosis-pseudoglioma syndrome
CRTAP	5	10	Bone fragility with contractures, arterial rupture, and deafness; Cole-carpenter syndrome; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
GORAB	5	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Larsen syndrome; Osteoporosis; Osteoporosis-pseudoglioma syndrome
IFITM5	5	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis; Osteoporosis-pseudoglioma syndrome
LRP5	5	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis; Osteoporosis-pseudoglioma syndrome
PLS3	5	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis; Osteoporosis-pseudoglioma syndrome
SEC24D	5	10	Bone fragility with contractures, arterial rupture, and deafness; Cole-carpenter syndrome; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
SERPINF1	5	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis; Osteoporosis-pseudoglioma syndrome
SP7	5	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis; Osteoporosis-pseudoglioma syndrome
WNT1	5	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis; Osteoporosis-pseudoglioma syndrome
XYLT2	5	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Larsen syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
ALPL	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
B3GALT6	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Larsen syndrome; Osteoporosis-pseudoglioma syndrome
B3GAT3	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Larsen syndrome; Osteoporosis-pseudoglioma syndrome
BMP1	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
CCDC134	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
CHST3	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Larsen syndrome; Osteoporosis-pseudoglioma syndrome
CREB3L1	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
FKBP10	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
KDELR2	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
MBTPS2	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
MESD	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
P3H1	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
PLOD2	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
PPIB	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
SERPINH1	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
SPARC	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
TENT5A	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
TMEM38B	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
XYLT1	4	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Larsen syndrome; Osteoporosis-pseudoglioma syndrome
COPB2	3	10	Bone fragility with contractures, arterial rupture, and deafness; Osteoporosis; Osteoporosis-pseudoglioma syndrome
CSGALNACT1	3	10	Desbuquois syndrome; Larsen syndrome; skeletal dysplasia, mild, with joint laxity and advanced bone age
LIFR	3	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteoporosis-pseudoglioma syndrome
NBAS	3	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteoporosis-pseudoglioma syndrome
P4HA1	3	10	Bone fragility with contractures, arterial rupture, and deafness; Larsen syndrome; Osteoporosis-pseudoglioma syndrome
PHLDB1	3	10	Bone fragility with contractures, arterial rupture, and deafness; Osteogenesis imperfecta; Osteoporosis-pseudoglioma syndrome
PLOD3	3	10	Bone fragility with contractures, arterial rupture, and deafness; Larsen syndrome; Osteoporosis-pseudoglioma syndrome
SGMS2	3	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteoporosis-pseudoglioma syndrome
SLC10A7	3	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteoporosis-pseudoglioma syndrome
TAPT1	3	10	Bone fragility with contractures, arterial rupture, and deafness; Desbuquois syndrome; Osteoporosis-pseudoglioma syndrome
AMBN	2	10	Bone fragility with contractures, arterial rupture, and deafness; Osteoporosis-pseudoglioma syndrome
ANO5	2	10	Desbuquois syndrome; Osteogenesis imperfecta
ANTXR2	2	10	Desbuquois syndrome; Osteoporosis
BMP2	2	10	Desbuquois syndrome; Osteoporosis
CA2	2	10	Desbuquois syndrome; Osteoporosis
CANT1	2	10	Desbuquois syndrome; Larsen syndrome
COL11A1	2	10	Desbuquois syndrome; Osteogenesis imperfecta
DSPP	2	10	Bone fragility with contractures, arterial rupture, and deafness; Osteoporosis-pseudoglioma syndrome
EMILIN1	2	10	Bone fragility with contractures, arterial rupture, and deafness; Osteoporosis-pseudoglioma syndrome
FGFR3	2	10	Desbuquois syndrome; Larsen syndrome
FLNB	2	10	Desbuquois syndrome; Larsen syndrome
GALNT3	2	10	Desbuquois syndrome; Osteoporosis
GPC6	2	10	Desbuquois syndrome; Osteoporosis
GZF1	2	10	Desbuquois syndrome; Larsen syndrome
IDH2	2	10	Desbuquois syndrome; Osteoporosis
IGF1R	2	10	Desbuquois syndrome; Osteoporosis
IL1RN	2	10	Desbuquois syndrome; Osteoporosis
KIF22	2	10	Desbuquois syndrome; Larsen syndrome
KIF5B	2	10	Bone fragility with contractures, arterial rupture, and deafness; Osteoporosis-pseudoglioma syndrome
KL	2	10	Desbuquois syndrome; Osteoporosis
MECOM	2	10	Desbuquois syndrome; Osteoporosis
MIA3	2	10	Bone fragility with contractures, arterial rupture, and deafness; Osteoporosis-pseudoglioma syndrome
OFD1	2	10	Desbuquois syndrome; Osteoporosis
PGGHG	2	10	Osteogenesis imperfecta; Osteoporosis
PIEZO2	2	10	Larsen syndrome; Osteoporosis
PPP1R21	2	10	Desbuquois syndrome; neurodevelopmental disorder with hypotonia, facial dysmorphism, and brain abnormalities
SEC16B	2	10	Bone fragility with contractures, arterial rupture, and deafness; Osteoporosis-pseudoglioma syndrome
SFRP4	2	10	Desbuquois syndrome; Osteoporosis
SKI	2	10	Desbuquois syndrome; Larsen syndrome
TGFB1	2	10	Desbuquois syndrome; Osteoporosis
TNFRSF11A	2	10	Desbuquois syndrome; Osteoporosis
TNFRSF11B	2	10	Desbuquois syndrome; Osteoporosis
TNFSF11	2	10	Desbuquois syndrome; Osteoporosis
WNT11	2	10	Bone fragility with contractures, arterial rupture, and deafness; Osteoporosis-pseudoglioma syndrome