# GeDiPNet Cluster 127 -- Enriched Pathways -- generated 2026-10-07 03:15:39
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Proteoglycans in cancer	KEGG	55	COL1A1, COL1A2, WNT1, WNT11, ACTB, BRAF, CBL, CDC42, FGFR1, FLNA, FN1, FZD2	204	705	4.59	1.820e-22	2.284e-19
Pathways in cancer	KEGG	91	LRP5, WNT1, WNT11, APC2, BMP2, BRAF, CBL, CDC42, CREBBP, CSF1R, DLL3, DLL4	533	705	2.91	5.028e-21	4.706e-18
Signaling pathways regulating pluripotency of stem cells	KEGG	41	LIFR, WNT1, WNT11, ACVR1, APC2, BMPR1B, DLX5, DVL1, DVL3, FGFR1, FGFR2, FGFR3	144	705	4.85	5.710e-18	3.251e-15
Breast cancer	KEGG	41	LRP5, WNT1, WNT11, APC2, BRAF, DLL3, DLL4, DVL1, DVL3, FGF10, FGF23, FGF8	148	705	4.72	1.698e-17	8.844e-15
Hepatocellular carcinoma	KEGG	44	LRP5, WNT1, WNT11, ACTB, APC2, ARID1B, BRAF, DVL1, DVL3, FZD2, HRAS, IGF1R	170	705	4.41	1.872e-17	9.662e-15
Parathyroid hormone synthesis, secretion and action	KEGG	36	CREB3L1, LRP5, BRAF, CASR, CYP27B1, FGF23, FGFR1, GCM2, GNAI3, GNAS, KL, MAFB	115	705	5.33	2.103e-17	1.070e-14
Gastric cancer	KEGG	41	LRP5, WNT1, WNT11, APC2, BRAF, DVL1, DVL3, FGF10, FGF23, FGF8, FGF9, FGFR2	150	705	4.66	2.882e-17	1.421e-14
Hedgehog 'off' state	Reactome	24	DYNC2H1, FUZ, GLI2, GLI3, GNAS, GPR161, IFT122, IFT140, IFT172, IFT52, INTU, KIF7	56	705	7.30	1.397e-15	5.249e-13
Melanogenesis	KEGG	31	CREB3L1, WNT1, WNT11, CREBBP, DVL1, DVL3, EDN1, EP300, FZD2, GNAI3, GNAS, HRAS	101	705	5.23	6.761e-15	2.229e-12
Signaling by high-kinase activity BRAF mutants	Reactome	17	ACTB, BRAF, FN1, HRAS, KRAS, MAP2K1, MAP2K2, MAPK1, NRAS, RAF1, ACTG1, FGA	36	705	8.04	2.902e-12	5.753e-10
Chronic myeloid leukemia	KEGG	24	BRAF, CBL, HRAS, IKBKB, IKBKG, KRAS, MAP2K1, MAP2K2, MAPK1, MECOM, NRAS, PIK3R1	77	705	5.31	5.414e-12	1.022e-9
Endocrine resistance	KEGG	27	BRAF, DLL3, DLL4, GNAS, HRAS, IGF1, IGF1R, KRAS, MAP2K1, MAP2K2, MAPK1, MMP2	99	705	4.65	8.688e-12	1.573e-9
AGE-RAGE signaling pathway in diabetic complications	KEGG	27	COL1A1, COL1A2, CDC42, EDN1, FN1, HRAS, KRAS, MAPK1, MMP2, NRAS, PIK3R1, PLCB3	101	705	4.55	1.452e-11	2.498e-9
Human papillomavirus infection	KEGG	53	COL1A1, COL1A2, CREB3L1, WNT1, WNT11, APC2, ATP6V0A2, ATR, CDC42, COL2A1, COL9A1, COL9A2	333	705	2.71	2.146e-11	3.570e-9
MAP2K and MAPK activation	Reactome	17	ACTB, BRAF, FN1, HRAS, KRAS, MAP2K1, MAP2K2, MAPK1, NRAS, RAF1, ACTG1, FGA	40	705	7.24	2.398e-11	3.929e-9