# GeDiPNet Cluster 126 -- Enriched Pathways -- generated 2026-10-09 18:20:15
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
ABC transporters	KEGG	3	ABCC2, ABCC6, ABCG2	45	16	50.04	2.661e-5	7.394e-4
Heme degradation	Reactome	2	ABCC2, ABCG2	14	16	107.23	1.500e-4	3.024e-3
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	KEGG	2	XYLT1, XYLT2	21	16	71.49	3.443e-4	5.878e-3
Glycosaminoglycan biosynthesis - heparan sulfate / heparin	KEGG	2	XYLT1, XYLT2	24	16	62.55	4.515e-4	7.283e-3
A tetrasaccharide linker sequence is required for GAG synthesis	Reactome	2	XYLT1, XYLT2	26	16	57.74	5.308e-4	8.246e-3
Antifolate resistance	KEGG	2	ABCC2, ABCG2	30	16	50.04	7.083e-4	1.033e-2
Folate transport and metabolism	KEGG	2	ABCC2, ABCG2	31	16	48.43	7.565e-4	1.083e-2
Defective ABCC2 causes Dubin-Johnson syndrome	Reactome	1	ABCC2	1	16	750.63	1.332e-3	1.674e-2
Defective ABCC6 causes pseudoxanthoma elasticum (PXE)	Reactome	1	ABCC6	1	16	750.63	1.332e-3	1.674e-2
Pyrimidine metabolism	KEGG	2	ENPP1, CANT1	58	16	25.88	2.634e-3	2.790e-2
ABC-family proteins mediated transport	Reactome	2	ABCC2, ABCC6	81	16	18.53	5.071e-3	4.418e-2
Nucleotide metabolism	KEGG	2	ENPP1, CANT1	85	16	17.66	5.570e-3	4.706e-2
Bile secretion	KEGG	2	ABCC2, ABCG2	90	16	16.68	6.224e-3	5.078e-2
Vitamin B2 (riboflavin) metabolism	Reactome	1	ENPP1	7	16	107.23	9.291e-3	6.610e-2
Riboflavin metabolism	KEGG	1	ENPP1	8	16	93.83	1.061e-2	7.204e-2