# GeDiPNet Cluster 122 -- Enriched Pathways -- generated 2026-10-07 23:12:42
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Neuroactive ligand-receptor interaction	KEGG	63	AVP, GRP, HRH3, PDYN, POMC, TAC1, TRH, ADORA1, AGT, CHRM2, CRH, DRD2	370	216	9.47	1.293e-44	1.434e-40
cAMP signaling pathway	KEGG	41	GNAI1, GNAI3, POMC, ADORA1, CACNA1D, CHRM2, CRH, DRD2, EDN1, EDN2, EDN3, GCG	226	216	10.09	7.416e-30	2.007e-26
Hormone signaling	KEGG	40	AVP, GNAI1, GNAI3, PDYN, POMC, TRH, AGT, CRH, DRD2, GCG, GNAI2, GNRH1	219	216	10.16	3.001e-29	7.239e-26
Peptide ligand-binding receptors	Reactome	28	GRP, PDYN, POMC, TRH, AGT, EDN1, EDN2, EDN3, KNG1, NTS, UTS2, CCK	106	216	14.69	2.288e-25	3.847e-22
G alpha (q) signalling events	Reactome	28	APP, AVP, GRP, TAC1, TRH, AGT, EDN1, EDN2, EDN3, GCG, GNRH1, KNG1	172	216	9.05	3.152e-19	1.943e-16
Serotonergic synapse	KEGG	23	APP, GNAI1, GNAI3, CACNA1D, CYP2D6, GNAI2, HTR1A, CASP3, KCNN2, PTGS2, ALOX12, ALOX5	115	216	11.12	4.796e-18	2.498e-15
Chagas disease	KEGG	22	GNAI1, GNAI3, IL2, IL6, GNAI2, KNG1, CASP8, CXCL8, TNF, BDKRB2, CCL2, FOS	103	216	11.88	5.856e-18	2.954e-15
Inflammatory mediator regulation of TRP channels	KEGG	21	NGF, KNG1, MAP2K6, ALOX12, BDKRB1, BDKRB2, CAMK2A, HTR2A, IGF1, IL1B, MAPK8, MAPK9	99	216	11.79	3.991e-17	1.717e-14
Calcium signaling pathway	KEGG	30	NGF, CACNA1D, CHRM2, TACR1, DRD1, BDKRB1, BDKRB2, CACNA1H, CAMK2A, CCKBR, GDNF, GRIN1	254	216	6.57	1.619e-16	6.304e-14
G alpha (i) signalling events	Reactome	29	APP, GNAI1, GNAI3, HRH3, PDYN, POMC, ADORA1, AGT, CHRM2, GNAI2, HTR1A, KNG1	249	216	6.48	7.873e-16	2.818e-13
Circadian entrainment	KEGG	19	GNAI1, GNAI3, CACNA1D, GNAI2, CACNA1H, CAMK2A, FOS, GRIN1, GRIN2B, MAPK1, MAPK3, NOS1	97	216	10.89	6.394e-15	1.923e-12
Dopaminergic synapse	KEGG	21	GNAI1, GNAI3, CACNA1D, DRD2, GNAI2, DRD1, PPP1R1B, TH, CAMK2A, COMT, DRD3, FOS	132	216	8.85	1.829e-14	5.048e-12
Cocaine addiction	KEGG	14	GNAI1, GNAI3, PDYN, DRD2, GNAI2, DRD1, PPP1R1B, TH, GRIN1, GRIN2B, GRIA2, SLC6A3	49	216	15.89	9.414e-14	2.327e-11
AGE-RAGE signaling pathway in diabetic complications	KEGG	18	IL1A, IL6, AGT, EDN1, CASP3, CXCL8, TNF, AGER, CCL2, IL1B, MAPK1, MAPK3	101	216	9.91	1.907e-13	4.418e-11
Vascular smooth muscle contraction	KEGG	20	AVP, AGT, CACNA1D, EDN1, EDN2, EDN3, CALCA, ADM, MAPK1, MAPK3, PRKCE, PRKCG	134	216	8.30	2.756e-13	6.215e-11