# GeDiPNet Cluster 120 -- Enriched Pathways -- generated 2026-10-10 09:45:03
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Reactome	9	SMARCB1, SMARCA4, ARID1A, ARID1B, ARID2, SMARCA2, SMARCC2, SMARCD1, SMARCE1	38	33	86.20	4.177e-16	1.647e-13
ATP-dependent chromatin remodeling	KEGG	11	SMARCB1, SMARCA4, ARID1A, ARID1B, ARID2, BICRA, DPF2, SMARCA2, SMARCC2, SMARCD1, SMARCE1	117	33	34.22	7.509e-15	2.372e-12
RMTs methylate histone arginines	Reactome	9	SMARCB1, SMARCA4, ARID1A, ARID1B, ARID2, SMARCA2, SMARCC2, SMARCD1, SMARCE1	79	33	41.46	4.898e-13	1.111e-10
Hepatocellular carcinoma	KEGG	9	SMARCB1, SMARCA4, ARID1A, ARID1B, ARID2, SMARCA2, SMARCC2, SMARCD1, SMARCE1	170	33	19.27	5.316e-10	6.663e-8
Thermogenesis	KEGG	9	SMARCB1, SMARCA4, RPS6KA3, ARID1A, ARID1B, SMARCA2, SMARCC2, SMARCD1, SMARCE1	234	33	14.00	8.908e-9	8.260e-7
Deactivation of the beta-catenin transactivating complex	Reactome	2	SOX4, SOX2	42	33	17.33	5.886e-3	5.056e-2
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	Reactome	1	SOX2	3	33	121.31	8.221e-3	6.258e-2
RSK activation	Reactome	1	RPS6KA3	4	33	90.98	1.095e-2	7.498e-2
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	Reactome	1	RPS6KA3	5	33	72.79	1.367e-2	8.548e-2
PTK6 Regulates Cell Cycle	Reactome	1	CDKN1B	6	33	60.66	1.638e-2	9.529e-2
p53-Dependent G1 DNA Damage Response	Reactome	1	CDKN1B	7	33	51.99	1.908e-2	1.042e-1
2-LTR circle formation	Reactome	1	XRCC4	7	33	51.99	1.908e-2	1.042e-1
CREB phosphorylation	Reactome	1	RPS6KA3	7	33	51.99	1.908e-2	1.042e-1
Gastrin-CREB signalling pathway via PKC and MAPK	Reactome	1	RPS6KA3	9	33	40.44	2.447e-2	1.202e-1
AKT phosphorylates targets in the cytosol	Reactome	1	CDKN1B	11	33	33.09	2.983e-2	1.335e-1