# GeDiPNet Cluster 12 -- Top Shared Genes -- generated 2026-10-07 21:00:03
# Curated genes (disease_gdp) linked to 2 or more of this cluster's member diseases, most widely shared first. Data as of: 2026-10-07 03:15:01.
Gene	Member Diseases Linked	Cluster Size	Linked Diseases
G6PD	10	24	anemia, nonspherocytic hemolytic, due to G6PD deficiency; Anhidrotic ectodermal dysplasia with immunodeficiency, osteopetrosis, and lymphedema; Autoinflammatory disease, systemic, x-linked; Bloch sulzberger syndrome; Congenital nonspherocytic hemolytic anemia; G6PD deficiency; Glucose-6-phosphate dehydrogenase deficiency; Granulomatous disease; Hemolytic anemia; Hyper-igm immunodeficiency syndrome
IKBKG	8	24	Anhidrotic ectodermal dysplasia with immunodeficiency, osteopetrosis, and lymphedema; Autoinflammatory disease, systemic, x-linked; Bloch sulzberger syndrome; Congenital nonspherocytic hemolytic anemia; Glucose-6-phosphate dehydrogenase deficiency; Hyper-igm immunodeficiency syndrome; IKBKG-related immunodeficiency with or without ectodermal dysplasia; incontinentia pigmenti
GCLC	4	24	Congenital nonspherocytic hemolytic anemia; Coronary vessel anomalies; Hemolytic anemia; Hereditary hemolytic anemia
IFNG	4	24	Glucose-6-phosphate dehydrogenase deficiency; Granulomatous disease; Peritonitis; Pleural diseases
GPI	3	24	Congenital nonspherocytic hemolytic anemia; Hemolytic anemia; Hereditary hemolytic anemia
GSS	3	24	Congenital nonspherocytic hemolytic anemia; Hereditary hemolytic anemia; inherited glutathione synthetase deficiency
HK1	3	24	Congenital nonspherocytic hemolytic anemia; Hemolytic anemia; Hereditary hemolytic anemia
NT5C3A	3	24	Congenital nonspherocytic hemolytic anemia; Hemolytic anemia; Uridine monophosphate hydrolase deficiency
AK1	2	24	Congenital nonspherocytic hemolytic anemia; Hemolytic anemia
BPGM	2	24	Hemolytic anemia; Hereditary hemolytic anemia
CARD8	2	24	Occupational disease; Pleural diseases
DNAJC30	2	24	leber-like hereditary optic neuropathy, autosomal recessive 1; Williams syndrome
GATA1	2	24	Congenital nonspherocytic hemolytic anemia; Hemolytic anemia
GSR	2	24	Congenital nonspherocytic hemolytic anemia; Hemolytic anemia
HBB	2	24	Hemolytic anemia; Hereditary hemolytic anemia
IL6	2	24	Glucose-6-phosphate dehydrogenase deficiency; Pleural diseases
MSLN	2	24	Endometrioid carcinoma; Pleural diseases
NCF1	2	24	Granulomatous disease; Williams syndrome
PKLR	2	24	Congenital nonspherocytic hemolytic anemia; Hemolytic anemia
RNF157	2	24	Granulomatous disease; Williams syndrome
SBF2	2	24	Charcot-Marie-Tooth disease type 4B2; Hemolytic anemia
TGFB1	2	24	Occupational disease; Pleural diseases
TIMP2	2	24	Occupational disease; Pleural diseases
TNFRSF13B	2	24	Hyper-igm immunodeficiency syndrome; immunodeficiency, common variable, 2