# GeDiPNet Cluster 118 -- Enriched Pathways -- generated 2026-10-08 21:04:08
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Lipid and atherosclerosis	KEGG	49	CCL2, CD14, FOS, GSK3B, HSPA1A, IL1B, IL6, JUN, MMP9, PPP3CA, SOD2, TICAM2	216	265	10.28	3.660e-36	1.579e-32
Cytokine-cytokine receptor interaction	KEGG	53	CCL2, CSF3, CXCL10, EPO, IFNL3, IL10, IL12RB2, IL13RA2, IL18R1, IL1A, IL1B, IL1R1	298	265	8.06	2.095e-33	7.263e-30
Interleukin-4 and Interleukin-13 signaling	Reactome	31	CCL2, FGF2, FOS, IL10, IL13RA2, IL1A, IL1B, IL6, MMP9, PTGS2, TNF, VEGFA	108	265	13.01	1.920e-26	3.945e-23
TNF signaling pathway	KEGG	30	CCL2, CEBPB, CXCL10, FOS, IL18R1, IL1B, IL6, IRF1, JUN, MMP9, PTGS2, TNF	119	265	11.43	8.871e-24	1.172e-20
Toxoplasmosis	KEGG	28	HSPA1A, IL10, TLR2, TLR4, TNF, TNFRSF1A, ITGB1, LAMA1, NOS2, RELA, CASP3, CASP9	112	265	11.33	3.811e-22	4.028e-19
IL-17 signaling pathway	KEGG	26	CCL2, CEBPB, CSF3, CXCL10, FOS, GSK3B, IL1B, IL6, JUN, MMP9, PTGS2, TNF	94	265	12.54	7.245e-22	6.813e-19
Interleukin-10 signaling	Reactome	20	CCL2, CSF3, CXCL10, IL10, IL1A, IL1B, IL1R1, IL1RN, IL6, PTGS2, TNF, TNFRSF1A	47	265	19.29	2.092e-21	1.814e-18
Tuberculosis	KEGG	33	CD14, CEBPB, CLEC4E, IL10, IL1A, IL1B, IL6, PPP3CA, TLR1, TLR2, TLR4, TLR9	181	265	8.26	2.798e-21	2.321e-18
Kaposi sarcoma-associated herpesvirus infection	KEGG	34	BECN1, FGF2, FOS, GSK3B, IL6, JUN, PPP3CA, PTGS2, TNFRSF1A, VEGFA, ICAM1, RELA	196	265	7.86	3.577e-21	2.876e-18
Viral protein interaction with cytokine and cytokine receptor	KEGG	26	CCL2, CXCL10, IL10, IL18R1, IL2, IL6, TNF, TNFRSF14, TNFRSF1A, TNFSF10, CCL11, CCL13	100	265	11.78	4.148e-21	3.312e-18
Apoptosis	KEGG	28	FOS, JUN, PARP1, TNF, TNFRSF1A, TNFSF10, RELA, BBC3, CASP3, CASP9, CYCS, DIABLO	137	265	9.26	1.368e-19	8.929e-17
Chagas disease	KEGG	25	CCL2, FOS, IL10, IL1B, IL2, IL6, JUN, TLR2, TLR4, TLR9, TNF, TNFRSF1A	103	265	11.00	1.538e-19	9.925e-17
Measles	KEGG	28	FOS, GSK3B, HSPA1A, IL1A, IL1B, IL2, IL6, JUN, TLR2, TLR4, TLR9, RELA	139	265	9.13	2.067e-19	1.318e-16
Pathways in cancer	KEGG	51	EPO, FGF2, FOS, GSK3B, IL12RB2, IL2, IL6, IL7, JUN, MMP9, PTGS2, TRAF4	533	265	4.34	2.304e-19	1.453e-16
Human cytomegalovirus infection	KEGG	34	CCL2, GSK3B, IL1B, IL1R1, IL6, PPP3CA, PTGS2, TNF, TNFRSF1A, VEGFA, RELA, CASP3	226	265	6.82	3.910e-19	2.371e-16