# GeDiPNet Cluster 116 -- Enriched Pathways -- generated 2026-10-08 10:42:53
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
PI3K Cascade	Reactome	4	FGFR2, FGF8, FGFR1, KLB	39	36	34.22	5.189e-6	1.999e-4
FGFR1c ligand binding and activation	Reactome	3	FGF8, ANOS1, FGFR1	12	36	83.40	5.342e-6	2.050e-4
COPI-independent Golgi-to-ER retrograde traffic	Reactome	4	RAB18, RAB3GAP1, RAB3GAP2, TUBB3	51	36	26.17	1.537e-5	4.879e-4
Negative regulation of FGFR1 signaling	Reactome	3	FGF8, ANOS1, FGFR1	26	36	38.49	6.133e-5	1.524e-3
Constitutive Signaling by Aberrant PI3K in Cancer	Reactome	4	FGFR2, FGF8, FGFR1, KLB	75	36	17.79	7.102e-5	1.714e-3
PIP3 activates AKT signaling	Reactome	4	FGFR2, FGF8, FGFR1, KLB	93	36	14.35	1.642e-4	3.371e-3
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Reactome	4	FGFR2, FGF8, FGFR1, KLB	103	36	12.96	2.434e-4	4.606e-3
Signaling by activated point mutants of FGFR1	Reactome	2	FGF8, FGFR1	11	36	60.66	4.724e-4	7.800e-3
RAF/MAP kinase cascade	Reactome	4	FGFR2, FGF8, FGFR1, KLB	124	36	10.76	4.938e-4	8.059e-3
FGFR2c ligand binding and activation	Reactome	2	FGFR2, FGF8	13	36	51.32	6.674e-4	1.018e-2
Phospholipase C-mediated cascade; FGFR4	Reactome	2	FGF8, KLB	15	36	44.48	8.951e-4	1.276e-2
Phospholipase C-mediated cascade: FGFR1	Reactome	2	FGF8, FGFR1	16	36	41.70	1.021e-3	1.412e-2
Activated point mutants of FGFR2	Reactome	2	FGFR2, FGF8	17	36	39.25	1.155e-3	1.550e-2
Phospholipase C-mediated cascade; FGFR2	Reactome	2	FGFR2, FGF8	18	36	37.07	1.297e-3	1.695e-2
Downstream signaling of activated FGFR1	Reactome	2	FGF8, FGFR1	18	36	37.07	1.297e-3	1.695e-2