# GeDiPNet Cluster 114 -- Enriched Pathways -- generated 2026-10-07 19:48:52
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Pathways of neurodegeneration - multiple diseases	KEGG	11	SNCA, TNF, LRRK2, MAPT, ATXN2, ATXN3, ND1, PARK7, PINK1, PRKN, SNCAIP	480	48	5.73	2.190e-6	9.503e-5
Parkinson disease	KEGG	8	SNCA, LRRK2, MAPT, ND1, PARK7, PINK1, PRKN, SNCAIP	268	48	7.47	9.641e-6	3.255e-4
Glycosphingolipid metabolism	Reactome	4	PSAP, SMPD1, ARSA, ARSB	46	48	21.76	3.240e-5	8.904e-4
Lysosome	KEGG	5	PSAP, SMPD1, SCARB2, ARSA, ARSB	133	48	9.41	1.805e-4	3.614e-3
Josephin domain DUBs	Reactome	2	ATXN3, PRKN	12	48	41.70	1.006e-3	1.361e-2
The activation of arylsulfatases	Reactome	2	ARSA, ARSB	13	48	38.49	1.186e-3	1.539e-2
Sphingolipid metabolism	KEGG	3	PSAP, SMPD1, ARSA	54	48	13.90	1.288e-3	1.639e-2
Pink/Parkin Mediated Mitophagy	Reactome	2	PINK1, PRKN	22	48	22.75	3.434e-3	3.392e-2
Mismatch repair	KEGG	2	MSH6, RFC1	23	48	21.76	3.751e-3	3.598e-2
MPS VI - Maroteaux-Lamy syndrome	Reactome	1	ARSB	1	48	250.21	3.997e-3	3.767e-2
Asthma	KEGG	2	TNF, HLA-DRA	32	48	15.64	7.188e-3	5.561e-2
Defective Mismatch Repair Associated With MSH6	Reactome	1	MSH6	2	48	125.10	7.978e-3	5.956e-2
NTF3 activates NTRK3 signaling	Reactome	1	NTRK3	2	48	125.10	7.978e-3	5.956e-2
Amyloid fiber formation	Reactome	3	SNCA, PRKN, SNCAIP	109	48	6.89	9.353e-3	6.586e-2
Allograft rejection	KEGG	2	TNF, HLA-DRA	39	48	12.83	1.055e-2	7.102e-2