# GeDiPNet Cluster 113 -- Enriched Pathways -- generated 2026-10-07 14:43:21
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Nucleotide excision repair	KEGG	10	ERCC2, ERCC3, GTF2H5, BIVM-ERCC5, DDB2, ERCC1, ERCC4, ERCC5, XPA, XPC	63	21	90.78	2.516e-18	1.561e-15
Formation of Incision Complex in GG-NER	Reactome	9	ERCC2, ERCC3, GTF2H5, DDB2, ERCC1, ERCC4, ERCC5, XPA, XPC	43	21	119.70	1.125e-17	6.005e-15
Dual Incision in GG-NER	Reactome	8	ERCC2, ERCC3, GTF2H5, DDB2, ERCC1, ERCC4, ERCC5, XPA	41	21	111.59	1.758e-15	6.539e-13
Dual incision in TC-NER	Reactome	7	ERCC2, ERCC3, GTF2H5, ERCC1, ERCC4, ERCC5, XPA	66	21	60.66	1.194e-11	2.097e-9
Cytosolic tRNA aminoacylation	Reactome	4	AARS1, CARS1, TARS1, MARS1	24	21	95.32	7.175e-8	4.892e-6
Basal transcription factors	KEGG	4	ERCC2, ERCC3, GTF2E2, GTF2H5	44	21	51.99	8.961e-7	4.434e-5
RNA Polymerase II Promoter Escape	Reactome	4	ERCC2, ERCC3, GTF2E2, GTF2H5	47	21	48.67	1.173e-6	5.602e-5
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	Reactome	4	ERCC2, ERCC3, GTF2E2, GTF2H5	47	21	48.67	1.173e-6	5.602e-5
RNA Polymerase II Transcription Initiation	Reactome	4	ERCC2, ERCC3, GTF2E2, GTF2H5	47	21	48.67	1.173e-6	5.602e-5
RNA Polymerase II Transcription Initiation And Promoter Clearance	Reactome	4	ERCC2, ERCC3, GTF2E2, GTF2H5	47	21	48.67	1.173e-6	5.602e-5
Formation of TC-NER Pre-Incision Complex	Reactome	4	ERCC2, ERCC3, GTF2H5, XPA	54	21	42.36	2.064e-6	9.036e-5
TP53 Regulates Transcription of DNA Repair Genes	Reactome	4	ERCC2, ERCC3, GTF2H5, DDB2	65	21	35.19	4.364e-6	1.698e-4
Aminoacyl-tRNA biosynthesis	KEGG	4	AARS1, CARS1, TARS1, MARS1	66	21	34.66	4.640e-6	1.789e-4
RNA Polymerase II Pre-transcription Events	Reactome	4	ERCC2, ERCC3, GTF2E2, GTF2H5	84	21	27.23	1.217e-5	3.957e-4
RNA Pol II CTD phosphorylation and interaction with CE	Reactome	3	ERCC2, ERCC3, GTF2H5	27	21	63.54	1.312e-5	4.206e-4