# GeDiPNet Cluster 112 -- Enriched Pathways -- generated 2026-10-09 04:56:49
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Metabolism of folate and pterines	Reactome	3	MTHFR, SLC19A1, MTHFD1	17	36	58.87	1.634e-5	4.924e-4
Folate transport and metabolism	KEGG	3	MTHFR, SLC19A1, MTHFD1	31	36	32.28	1.050e-4	2.277e-3
Detoxification of Reactive Oxygen Species	Reactome	3	PRDX2, PRDX6, SOD1	34	36	29.44	1.389e-4	2.840e-3
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	Reactome	2	ISL1, GATA4	7	36	95.32	1.817e-4	3.524e-3
Assembly of collagen fibrils and other multimeric structures	Reactome	3	COL11A2, MMP9, COL18A1	51	36	19.62	4.666e-4	7.489e-3
Collagen degradation	Reactome	3	COL11A2, MMP9, COL18A1	52	36	19.25	4.942e-4	7.811e-3
Physiological factors	Reactome	2	NKX2-5, GATA4	12	36	55.60	5.658e-4	8.668e-3
YAP1- and WWTR1 (TAZ)-stimulated gene expression	Reactome	2	NKX2-5, GATA4	14	36	47.66	7.772e-4	1.107e-2
Factors involved in megakaryocyte development and platelet production	Reactome	3	ZFPM2, GATA1, GATA4	99	36	10.11	3.185e-3	3.192e-2
Antifolate resistance	KEGG	2	MTHFR, SLC19A1	30	36	22.24	3.605e-3	3.487e-2
Activation of Matrix Metalloproteinases	Reactome	2	MMP9, COL18A1	33	36	20.22	4.351e-3	3.984e-2
Signaling by SCF-KIT	Reactome	2	YES1, MMP9	37	36	18.03	5.447e-3	4.642e-2
Thyroid hormone signaling pathway	KEGG	3	MED13L, RCAN1, GATA4	122	36	8.20	5.719e-3	4.788e-2
One carbon pool by folate	KEGG	2	MTHFR, MTHFD1	38	36	17.56	5.739e-3	4.798e-2
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Reactome	2	SOD1, PAK2	38	36	17.56	5.739e-3	4.798e-2