# GeDiPNet Cluster 104 -- Enriched Pathways -- generated 2026-10-08 12:18:12
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Inflammatory bowel disease	KEGG	16	HLA-DRB5, STAT4, HLA-DPA1, HLA-DPB1, HLA-DRA, IL1A, IL1B, TNF, HLA-DRB1, HLA-DQA1, IL13, TLR2	66	97	30.02	5.560e-20	3.809e-17
Type I diabetes mellitus	KEGG	13	HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-B, HLA-DRA, IL1A, IL1B, TNF, HLA-DRB1, HLA-DQA1, HLA-A, IL2	44	97	36.58	1.145e-17	5.408e-15
Graft-versus-host disease	KEGG	13	HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-B, HLA-DRA, IL1A, IL1B, TNF, HLA-DRB1, HLA-DQA1, HLA-A, IL2	45	97	35.77	1.600e-17	7.460e-15
Leishmaniasis	KEGG	14	FCGR3B, HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, IL1A, IL1B, TNF, HLA-DRB1, FCGR2A, HLA-DQA1, IRAK1	78	97	22.22	1.278e-15	4.364e-13
Allograft rejection	KEGG	11	HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-B, HLA-DRA, TNF, HLA-DRB1, HLA-DQA1, HLA-A, IL2, HLA-DQB1	39	97	34.92	7.412e-15	2.217e-12
Phagosome	KEGG	16	FCGR2B, FCGR3B, HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-B, HLA-DRA, MBL2, HLA-DRB1, FCGR2A, HLA-DQA1, TAP1	155	97	12.78	8.746e-14	2.181e-11
Th17 cell differentiation	KEGG	14	HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, IL1B, HLA-DRB1, HLA-DQA1, TGFBR1, IL17A, IL17F, IRF4, IL2	109	97	15.90	1.636e-13	3.855e-11
Interferon gamma signaling	Reactome	13	HLA-DRB5, IRF5, HLA-DPA1, HLA-DPB1, TRIM10, TRIM31, HLA-B, HLA-DRA, HLA-DRB1, HLA-DQA1, IRF4, HLA-A	87	97	18.50	1.704e-13	3.998e-11
Translocation of ZAP-70 to Immunological synapse	Reactome	8	HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, HLA-DRB1, HLA-DQA1, CD247, HLA-DQB1	19	97	52.13	9.483e-13	1.938e-10
Tuberculosis	KEGG	16	FCGR2B, FCGR3B, HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, IL1A, IL1B, TNF, HLA-DRB1, FCGR2A, HLA-DQA1	181	97	10.94	9.960e-13	2.024e-10
Herpes simplex virus 1 infection	KEGG	16	HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-B, HLA-DRA, IL1B, TNF, HLA-DRB1, HLA-DQA1, IRAK1, TAP1, TAP2	182	97	10.88	1.085e-12	2.189e-10
Antigen processing and presentation	KEGG	12	HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-B, HLA-DRA, TNF, HLA-DRB1, HLA-DQA1, TAP1, TAP2, HLA-A, HLA-DQB1	81	97	18.34	1.714e-12	3.359e-10
Asthma	KEGG	9	HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, TNF, HLA-DRB1, HLA-DQA1, IL13, HLA-DQB1	32	97	34.82	2.410e-12	4.571e-10
Phosphorylation of CD3 and TCR zeta chains	Reactome	8	HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, HLA-DRB1, HLA-DQA1, CD247, HLA-DQB1	22	97	45.02	3.933e-12	7.202e-10
PD-1 signaling	Reactome	8	HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, HLA-DRB1, HLA-DQA1, CD247, HLA-DQB1	23	97	43.07	5.991e-12	1.069e-9