# GeDiPNet Cluster 103 -- Enriched Pathways -- generated 2026-10-07 06:30:04
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Inflammatory bowel disease	KEGG	19	IL23R, NFKB1, GATA3, IL5, TLR2, TLR4, HLA-DQA1, HLA-DRB1, RORA, SMAD3, STAT6, TGFB1	66	261	13.25	9.167e-17	4.159e-14
Th17 cell differentiation	KEGG	18	IL23R, NFKB1, GATA3, HLA-DQA1, HLA-DRB1, JAK2, RORA, SMAD3, STAT6, TGFB1, IRF4, IL4R	109	261	7.60	1.854e-11	3.141e-9
Th1 and Th2 cell differentiation	KEGG	13	NFKB1, GATA3, IL5, HLA-DQA1, HLA-DRB1, JAK2, STAT6, IL4R, CD247, HLA-DQB1, HLA-DRA, IL2	93	261	6.43	9.881e-8	6.462e-6
Intestinal immune network for IgA production	KEGG	9	LTBR, TNFRSF13B, IL5, HLA-DQA1, HLA-DRB1, TGFB1, HLA-DQB1, HLA-DRA, IL2	50	261	8.28	1.083e-6	5.239e-5
Phosphorylation of CD3 and TCR zeta chains	Reactome	6	HLA-DQA1, HLA-DRB1, CD247, HLA-DQB1, HLA-DRA, PTPRC	22	261	12.55	5.539e-6	2.060e-4
Leishmaniasis	KEGG	10	NFKB1, MYD88, TLR2, TLR4, HLA-DQA1, HLA-DRB1, JAK2, TGFB1, HLA-DQB1, HLA-DRA	78	261	5.90	6.784e-6	2.425e-4
Allograft rejection	KEGG	7	IL5, HLA-DQA1, HLA-DRB1, HLA-B, HLA-DQB1, HLA-DRA, IL2	39	261	8.26	1.792e-5	5.465e-4
Interferon gamma signaling	Reactome	10	HLA-DQA1, HLA-DRB1, CAMK2G, JAK2, MT2A, HLA-B, IRF1, IRF4, HLA-DQB1, HLA-DRA	87	261	5.29	1.817e-5	5.530e-4
Interleukin-4 and Interleukin-13 signaling	Reactome	11	IL23R, GATA3, FOXO1, JAK2, RHOU, RORA, STAT6, TGFB1, ALOX15, IRF4, IL4R	108	261	4.69	2.216e-5	6.494e-4
Toxoplasmosis	KEGG	11	NFKB1, MYD88, TLR2, TLR4, HLA-DQA1, HLA-DRB1, JAK2, TGFB1, HLA-DQB1, HLA-DRA, LAMA3	112	261	4.52	3.123e-5	8.629e-4
Tuberculosis	KEGG	14	NFKB1, MYD88, TLR2, TLR4, HLA-DQA1, HLA-DRB1, CAMK2G, JAK2, TGFB1, RAB5B, FCER1G, HLA-DQB1	181	261	3.56	4.046e-5	1.076e-3
MyD88 deficiency (TLR2/4)	Reactome	4	MYD88, TLR2, TLR4, TLR1	10	261	18.41	4.129e-5	1.094e-3
Translocation of ZAP-70 to Immunological synapse	Reactome	5	HLA-DQA1, HLA-DRB1, CD247, HLA-DQB1, HLA-DRA	19	261	12.11	4.226e-5	1.115e-3
Asthma	KEGG	6	IL5, HLA-DQA1, HLA-DRB1, FCER1G, HLA-DQB1, HLA-DRA	32	261	8.63	5.605e-5	1.404e-3
IRAK4 deficiency (TLR2/4)	Reactome	4	MYD88, TLR2, TLR4, TLR1	11	261	16.73	6.378e-5	1.555e-3